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Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC)
Zhao, Y. -F.1; Ma, X. -Q.1; Wang, R.1; Yan, X. -Y.2; Li, Z. -S.3; Zou, D. -W.3; He, J.1
刊名ALIMENTARY PHARMACOLOGY & THERAPEUTICS
2011-10-01
DOI10.1111/j.1365-2036.2011.04809.x
34期:8页:1020-1029
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Pharmacology & Pharmacy
研究领域[WOS]Gastroenterology & Hepatology ; Pharmacology & Pharmacy
关键词[WOS]GASTROESOPHAGEAL-REFLUX DISEASE ; SELF-REPORTED CONSTIPATION ; BODY-MASS INDEX ; QUALITY-OF-LIFE ; SURVEY METHODOLOGY ; JAPANESE WOMEN ; NORTH-AMERICA ; PREVALENCE ; SYMPTOMS ; DISORDERS
英文摘要

Background

The epidemiology and effects of functional constipation (FC) on Chinese people remain unclear.

Aim

To investigate the epidemiology of FC and its distinction from constipation-predominant irritable bowel syndrome (IBS-C) in China.

Methods

A cross-sectional survey was conducted in a representative adult Chinese population (n = 16 078), which was selected from five regions using randomised, stratified, multistage sampling methodology. All respondents completed the modified Rome II questionnaire; 20% were asked to complete the 36-item Short Form (SF-36) and the Epworth Sleepiness Scale (ESS).

Results

Overall, 948 respondents (6%) had FC and FC was more prevalent in women than in men (8% vs. 4%, P < 0.001). Straining and hard stools were the two most frequent symptoms. FC was associated significantly with dyspepsia and abdominal bloating. All SF-36 domain scores were lower for respondents with FC than for those without. The prevalence of clinically meaningful daytime sleepiness was significantly higher in respondents with FC than in those without (22% vs. 14%, P = 0.003). Respondents with FC were more likely to strain, but less likely to have a feeling of incomplete emptying after a bowel movement than those with IBS-C. Respondents with IBS-C experienced similar demographics, quality of life and daytime sleepiness to those with FC.

Conclusions

The prevalence of FC in China is substantially lower than that in Western countries. FC has negative effects on quality of life and daytime sleepiness. The demographics and burden of illness are similar between FC and IBS-C, although the clinical symptoms are somewhat different. Aliment Pharmacol Ther 2011; 34: 1020-1029

语种英语
WOS记录号WOS:000295082000021
资助机构AstraZeneca R&amp ; D, Molndal, Sweden
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57516
专题北京大学临床研究所
北京大学第二临床医学院_重症医学科
作者单位1.Peking Univ, Clin Res Inst, Beijing 100871, Peoples R China
2.Second Mil Med Univ, Dept Hlth Stat, Shanghai 200433, Peoples R China
3.Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Y. -F.,Ma, X. -Q.,Wang, R.,et al. Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC)[J]. ALIMENTARY PHARMACOLOGY &amp; THERAPEUTICS,2011,34(8):1020-1029.
APA Zhao, Y. -F..,Ma, X. -Q..,Wang, R..,Yan, X. -Y..,Li, Z. -S..,...&He, J..(2011).Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC).ALIMENTARY PHARMACOLOGY & THERAPEUTICS,34(8),1020-1029.
MLA Zhao, Y. -F.,et al."Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC)".ALIMENTARY PHARMACOLOGY & THERAPEUTICS 34.8(2011):1020-1029.
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