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学科主题: 临床医学
题名:
A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study of the Effects of Qili Qiangxin Capsules in Patients With Chronic Heart Failure
作者: Li, Xinli1; Zhang, Jian2,3; Huang, Jun1; Ma, Aiqun4; Yang, Jiefu5; Li, Weimin6; Wu, Zonggui7; Yao, Chen8; Zhang, Yuhui2,3; Yao, Wenming1; Zhang, Boli9; Gao, Runlin2,3; Efficacy Safety Qili Qiangxin Caps
关键词: chronic heart failure ; qili qiangxin capsules ; randomized controlled trial
刊名: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
发表日期: 2013-09-17
DOI: 10.1016/j.jacc.2013.05.035
卷: 62, 期:12, 页:1065-1072
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: BRAIN NATRIURETIC PEPTIDE ; TASK-FORCE ; DIAGNOSIS ; COLLABORATION ; DYSFUNCTION ; GUIDELINES ; SOCIETY ; RATS
英文摘要:

Objectives The purpose of this study was to assess the effects of qili qiangxin capsules in patients with chronic heart failure (CHF).

Background Qili qiangxin capsules are a traditional Chinese medicine that has been approved in China for the treatment of CHF, but the evidence supporting its efficacy remains unclear.

Methods A total of 512 patients with CHF were enrolled and randomly assigned to receive the placebo or qili qiangxin capsules in addition to their standard medications for the treatment of CHF. The primary endpoint was the reduction or percent change in the plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) level during 12 weeks of treatment.

Results At the 12-week follow-up, a significant reduction in the NT-proBNP level from baseline was observed in both groups, but the qili qiangxin capsule group demonstrated a significantly greater reduction than the placebo group (p = 0.002); 47.95% of patients in the qili qiangxin capsule group demonstrated reductions in NT-proBNP levels of at least 30% compared with 31.98% of patients in the placebo group (p < 0.001). Treatment with qili qiangxin capsules also demonstrated superior performance in comparison to the placebo with respect to New York Heart Association functional classification, left ventricular ejection fraction, 6-min walking distance, and quality of life.

Conclusions On a background of standard treatment, qili qiangxin capsules further reduced the levels of NT-proBNP. Together, our data suggest that qili qiangxin capsules could be used in combination therapy for CHF. (C) 2013 by the American College of Cardiology Foundation

语种: 英语
所属项目编号: 2012CB518606 ; PAPD2010-2013
项目资助者: 973 Program of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions ; Shijiazhuang Yiling Pharmaceutical Co., Ltd.
WOS记录号: WOS:000324047800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57517
Appears in Collections:北京大学临床研究所_期刊论文

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作者单位: 1.Minist Hlth, Beijing Hosp, Beijing, Peoples R China
2.Harbin Med Univ, Affiliated Hosp 1, Harbin, Peoples R China
3.Nanjing Med Univ, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
4.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, Beijing 100037, Peoples R China
5.Peking Union Med Coll, Beijing 100037, Peoples R China
6.Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Xian 710049, Peoples R China
7.Second Mil Med Univ, Shanghai Changzheng Hosp, Shanghai, Peoples R China
8.Peking Univ, Clin Res Inst, Dept Biostat, Beijing 100871, Peoples R China
9.Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin, Peoples R China

Recommended Citation:
Li, Xinli,Zhang, Jian,Huang, Jun,et al. A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study of the Effects of Qili Qiangxin Capsules in Patients With Chronic Heart Failure[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,2013,62(12):1065-1072.
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