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Monoamine oxidase a gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder
Li, Jun; Kang, Chuanyuan; Zhang, Haobo; Wang, Yufeng; Zhou, Rulun; Wang, Bing; Guan, Lili; Yang, Li; Faraone, Stephen V.
关键词Serotonin Doparaine Mao Attention-deficit/hyperactivity Disorder (Adhd) Outcome
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2007-06-05
DOI10.1002/ajmg.b.30421
144B期:4页:430-433
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; AGE-DEPENDENT DECLINE ; 5-HT1B RECEPTOR GENE ; RESEARCH CRITERIA ; ADHD ; SYMPTOMS ; CHILDREN ; BOYS ; ASSOCIATION ; PERSISTENCE
英文摘要

ADHD is generally deemed to be a highly heritable disorder with mean heritability of 0.75. The enzyme monoamine oxidase (MAO), which has both A and B types, has long been considered a candidate pathological substrate for ADHD, and more recently, the genes for both MAO enzymes have been examined as mediators of the illness. Previous studies indicated that 30-50% of children with ADHD will experience symptoms that persist into adolescence and will have more significant impairment in social and neuropsychological functioning compared to those whose symptoms have remitted. Genes may also influence these characteristics of the disorder, and in this context MAO genes may also be candidates for moderating the presentation of ADHD. The current study examined the association between adolescent outcome of ADHD and MAO gene polymorphisms, including the 941T > G polymorphism in exon 8 (rs1799835) and 1460C > T polymorphism in exon 14 (rs1137070) of the MAOA gene, and the A > G polymorphism. in intron13 (rs1799836), C > T polymorphism in the 3′UTR (rs1040399), and 2327T > C polymorphism. in exon15 of the MAOB gene. Significant associations were observed between the MAOA gene polymorphisms and ADHD remission. Due to the small sample size and the possibility of phenotypic and etiologic heterogeneity of ADHD outcomes across ethnic or geographic groups, these results must be replicated before they can be generalized to other populations. (c) 2007 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000246982700005
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被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57521
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Hosp 6, Beijing 100083, Peoples R China
2.SUNY Upstate Med Univ, Med Genet Res Program, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA
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Li, Jun,Kang, Chuanyuan,Zhang, Haobo,et al. Monoamine oxidase a gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2007,144B(4):430-433.
APA Li, Jun.,Kang, Chuanyuan.,Zhang, Haobo.,Wang, Yufeng.,Zhou, Rulun.,...&Faraone, Stephen V..(2007).Monoamine oxidase a gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,144B(4),430-433.
MLA Li, Jun,et al."Monoamine oxidase a gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 144B.4(2007):430-433.
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