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学科主题: 临床医学
题名:
A PRECLINICAL IN VIVO INVESTIGATION OF HIGH-INTENSITY FOCUSED ULTRASOUND COMBINED WITH RADIOTHERAPY
作者: Liu, Chao-Xing1; Gao, Xian-Shu1; Xiong, Liu-Lin3; Ge, Hui-Yu4; He, Xin-Yong1; Li, Ting2; Zhang, Hong-Juan5; Bai, Hong-Zhong6; Lin, Qiang1; Zhang, Ming1; Zhao, Jing1; Xiong, Wei1; Bai, Yu; Asaumi, Junichi7
关键词: High-intensity focused ultrasound (HIFU) ; Radiotherapy (RT) ; Swine ; Pancreas ; Injury
刊名: ULTRASOUND IN MEDICINE AND BIOLOGY
发表日期: 2011
DOI: 10.1016/j.ultrasmedbio.2010.10.001
卷: 37, 期:1, 页:69-77
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: PROSTATE-CANCER ; BREAST-CANCER ; THERAPY ; ABLATION ; HIFU
英文摘要:

This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region. (E-mail: xsgao777@hotmail.com) (C) 2011 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.

语种: 英语
所属项目编号: WKJ2006-1-007
项目资助者: Ministry of Health of the People&prime ; s Republic of China
WOS记录号: WOS:000285083600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57522
Appears in Collections:北京大学第一临床医学院_肿瘤化疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Radiat Oncol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Pathol, Beijing 100034, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 3, Dept Ultrasound, Beijing 100871, Peoples R China
5.First Hosp Shijiazhuang City, Dept Radiat Oncol, Shijiazhuang, Hebei Province, Peoples R China
6.Hebei Chest Hosp, Dept Radiol, Shijiazhuang, Peoples R China
7.Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral & Maxillofacial Radiol, Okayama, Japan

Recommended Citation:
Liu, Chao-Xing,Gao, Xian-Shu,Xiong, Liu-Lin,et al. A PRECLINICAL IN VIVO INVESTIGATION OF HIGH-INTENSITY FOCUSED ULTRASOUND COMBINED WITH RADIOTHERAPY[J]. ULTRASOUND IN MEDICINE AND BIOLOGY,2011,37(1):69-77.
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