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学科主题: 临床医学
题名:
The appearance of ADCs in the non-affected areas of the patients with MELAS
作者: Liu, Zhenghua1; Liu, Xiwei1; Hui, Lihong1; Zhao, Danhua2; Wang, Xiaoying1; Xie, Sheng1; Xiao, Jiangxi1; Jiang, Xuexiang1
关键词: MELAS ; Vasogenic edema ; MRI ; DWI ; ADC
刊名: NEURORADIOLOGY
发表日期: 2011-04-01
DOI: 10.1007/s00234-010-0729-y
卷: 53, 期:4, 页:227-232
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: STROKE-LIKE EPISODES ; MAGNETIC-RESONANCE-SPECTROSCOPY ; CEREBRAL-BLOOD-FLOW ; LACTIC-ACIDOSIS ; MITOCHONDRIAL DISORDERS ; VASCULAR INVOLVEMENT ; GLUCOSE-METABOLISM ; MUTATION ; EDEMA ; ENCEPHALOPATHY
英文摘要:

The exact mechanism of the mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) remain unclear. Diffusion-weighted imaging (DWI) is a magnetic resonance (MR) imaging technique for studying the pathophysiologic change of the MELAS. The purpose of the study is to see whether the apparent diffusion coefficient (ADC) of MELAS in the non-affected areas is different from the ADC of the normal subjects and to speculate the pathophysiological mechanisms of the MELAS.

Sixteen cases of MELAS were retrospectively analyzed. Thirty healthy subjects were chosen to constitute the control group. All of them were performed on the 3.0T whole-body MR scanner with axial view T2 fluid attenuated inversion recovery (flair), T2-weighted imaging, T1flair, and DWI. An ADC map was reconstructed in the workstation. Two to five regions of interest were put in the non-affected frontal lobe and basal ganglia. All data took statistical analysis.

There were significant differences between the ADC of the patients with MELAS and the controls in the non-affected areas, including the superior frontal gyrus, precentral gyrus, corpus striatum, thalamus, and white matter of the semi-oval centrum.

ADCs in the non-affected areas of the patients with MELAS are higher than those of the normal subjects. Pathological changes take place in the non-affected areas of the patients with MELAS.

语种: 英语
WOS记录号: WOS:000288557200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57523
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Radiol, Ctr Funct Imaging, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China

Recommended Citation:
Liu, Zhenghua,Liu, Xiwei,Hui, Lihong,et al. The appearance of ADCs in the non-affected areas of the patients with MELAS[J]. NEURORADIOLOGY,2011,53(4):227-232.
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