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Furazolidone, amoxicillin, bismuth and rabeprazole quadruple rescue therapy for the eradication of Helicobacter pylori
Cheng, Hong; Hu, Fu-Lian
关键词Helicobacter Pylori Rescue Therapy Quadruple Therapy Furazolidone Low Dose
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2009-02-21
DOI10.3748/wjg.15.860
15期:7页:860-864
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]MAASTRICHT-III CONSENSUS ; PEPTIC-ULCER DISEASE ; METRONIDAZOLE RESISTANCE ; CLINICAL-PRACTICE ; TRIPLE THERAPIES ; MANAGEMENT ; INFECTION ; REGIMENS ; TRIAL ; MULTICENTER
英文摘要

AIM: To compare the efficacy and side effect profiles of three furazolidone and amoxicillin-based quadruple rescue therapies for the eradication of Helicobacter pylori (H pylori).

METHODS: Patients who failed in the H pylori eradication therapy for at least one course were randomly allocated into three groups. Group A received rebaprazole 10 mg + amoxicillin 1 g + furazolidone 100 mg, and bismuth subcitrate 220 mg, twice daily for 1 wk; group B received the same regimen of group A but for 2 wk; and group C received the same regimen of group 13, but furazolidone was replaced by furazolidone 100 mg three times daily. To record the side effect profiles at the end of the treatment, H pylori eradication was assessed with C-13-urea breath test 4 wk after therapy.

RESULTS: Sixty patients were enrolled including 28 males, and 20 patients in each group. The average age of the patients was 49.2 years, ranging from 18 to 84 years. H pylori eradication rates with per-protocol analysis were 82%, 89% and 90% in the three groups, respectively. Side effects were found in 11 patients, including mild dizziness, nausea, diarrhea and increased bowel movement. None of the 11 patients needed treatment for their side effects.

CONCLUSION: One- or two-week furazolidone and amoxicillin-based quadruple rescue therapy with a low dose furazolidone (100 mg bid) for the eradication of H pylori is effective. Extending the antibiotic course to 14 d could improve the eradication rates. (C) 2009 The WIG Press and Baishideng. All rights reserved.

语种英语
WOS记录号WOS:000263760500011
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57529
专题北京大学第一临床医学院_消化科
作者单位Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China
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GB/T 7714
Cheng, Hong,Hu, Fu-Lian. Furazolidone, amoxicillin, bismuth and rabeprazole quadruple rescue therapy for the eradication of Helicobacter pylori[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2009,15(7):860-864.
APA Cheng, Hong,&Hu, Fu-Lian.(2009).Furazolidone, amoxicillin, bismuth and rabeprazole quadruple rescue therapy for the eradication of Helicobacter pylori.WORLD JOURNAL OF GASTROENTEROLOGY,15(7),860-864.
MLA Cheng, Hong,et al."Furazolidone, amoxicillin, bismuth and rabeprazole quadruple rescue therapy for the eradication of Helicobacter pylori".WORLD JOURNAL OF GASTROENTEROLOGY 15.7(2009):860-864.
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