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学科主题: 临床医学
题名:
Furazolidone, amoxicillin, bismuth and rabeprazole quadruple rescue therapy for the eradication of Helicobacter pylori
作者: Cheng, Hong; Hu, Fu-Lian
关键词: Helicobacter pylori ; Rescue therapy ; Quadruple therapy ; Furazolidone ; Low dose
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2009-02-21
DOI: 10.3748/wjg.15.860
卷: 15, 期:7, 页:860-864
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: MAASTRICHT-III CONSENSUS ; PEPTIC-ULCER DISEASE ; METRONIDAZOLE RESISTANCE ; CLINICAL-PRACTICE ; TRIPLE THERAPIES ; MANAGEMENT ; INFECTION ; REGIMENS ; TRIAL ; MULTICENTER
英文摘要:

AIM: To compare the efficacy and side effect profiles of three furazolidone and amoxicillin-based quadruple rescue therapies for the eradication of Helicobacter pylori (H pylori).

METHODS: Patients who failed in the H pylori eradication therapy for at least one course were randomly allocated into three groups. Group A received rebaprazole 10 mg + amoxicillin 1 g + furazolidone 100 mg, and bismuth subcitrate 220 mg, twice daily for 1 wk; group B received the same regimen of group A but for 2 wk; and group C received the same regimen of group 13, but furazolidone was replaced by furazolidone 100 mg three times daily. To record the side effect profiles at the end of the treatment, H pylori eradication was assessed with C-13-urea breath test 4 wk after therapy.

RESULTS: Sixty patients were enrolled including 28 males, and 20 patients in each group. The average age of the patients was 49.2 years, ranging from 18 to 84 years. H pylori eradication rates with per-protocol analysis were 82%, 89% and 90% in the three groups, respectively. Side effects were found in 11 patients, including mild dizziness, nausea, diarrhea and increased bowel movement. None of the 11 patients needed treatment for their side effects.

CONCLUSION: One- or two-week furazolidone and amoxicillin-based quadruple rescue therapy with a low dose furazolidone (100 mg bid) for the eradication of H pylori is effective. Extending the antibiotic course to 14 d could improve the eradication rates. (C) 2009 The WIG Press and Baishideng. All rights reserved.

语种: 英语
WOS记录号: WOS:000263760500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57529
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China

Recommended Citation:
Cheng, Hong,Hu, Fu-Lian. Furazolidone, amoxicillin, bismuth and rabeprazole quadruple rescue therapy for the eradication of Helicobacter pylori[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2009,15(7):860-864.
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