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学科主题: 临床医学
题名:
POLYPOIDAL CHOROIDAL VASCULOPATHY Evidence-Based Guidelines for Clinical Diagnosis and Treatment
作者: Koh, Adrian H. C.; Chen, Lee-Jen1; Chen, Shih-Jen2; Chen, Youxin3; Giridhar, Anantharam4; Iida, Tomohiro5,6; Kim, Hakyoung7; Lai, Timothy Yuk Yau; Lee, Won Ki8; Li, Xiaoxin9; Lim, Tock Han10,11; Ruamviboonsuk, Paisan12; Sharma, Tarun13; Tang, Shibo14; Yuzawa, Mitsuko15; Expert PCV Panel
关键词: indocyanine green angiography ; pigment epithelium detachment ; polypoidal choroidal vasculopathy ; ranibizumab ; verteporfin PDT
刊名: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
发表日期: 2013-04-01
DOI: 10.1097/IAE.0b013e3182852446
卷: 33, 期:4, 页:686-716
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: INDOCYANINE GREEN ANGIOGRAPHY ; ENDOTHELIAL GROWTH-FACTOR ; VERTEPORFIN PHOTODYNAMIC THERAPY ; OPTICAL COHERENCE TOMOGRAPHY ; INTRAVITREAL BEVACIZUMAB INJECTION ; PIGMENT EPITHELIAL DETACHMENT ; BRANCHING VASCULAR NETWORKS ; MACULAR DEGENERATION ; JAPANESE PATIENTS ; CLINICOPATHOLOGICAL CORRELATION
英文摘要:

Background: Polypoidal choroidal vasculopathy (PCV) is an exudative maculopathy affecting vision, with clinical features distinct from neovascular age-related macular degeneration. Currently, no evidence-based guidelines exist for its diagnosis and treatment.

Methods: A panel of experts analyzed a systematic literature search on PCV together with results of the EVEREST trial, the only published randomized controlled clinical trial in PCV. At a subsequent Roundtable meeting, recommendations for the management of PCV were agreed based on this analysis and their own expert opinion.

Results: Diagnosis of PCV should be based on early-phase nodular hyperfluorescence from choroidal vasculature visualized using indocyanine green angiography. Recommended initial treatment of juxtafoveal and subfoveal PCV is either indocyanine green angiography-guided verteporfin photodynamic therapy or verteporfin photodynamic therapy plus 3 x 0.5 mg ranibizumab intravitreal injections 1 month apart. If there is incomplete regression of polyps by indocyanine green angiography, eyes should be retreated with verteporfin photodynamic therapy monotherapy or verteporfin photodynamic therapy plus ranibizumab. If there is complete regression of polyps by indocyanine green angiography, but there is leakage on fluorescein angiography and other clinical or anatomical signs of disease activity, eyes should be retreated with ranibizumab.

Conclusion: Practical guidance on the clinical management of PCV is proposed based on expert evaluation of current evidence. RETINA 33:686-716, 2013

语种: 英语
项目资助者: College of Ophthalmologists, Singapore
WOS记录号: WOS:000316801900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57531
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Surugadai Nihon Univ, Dept Ophthalmol, Chiyoda Ku, Tokyo, Japan
2.Mackay Mem Hosp, Dept Ophthalmol, Taipei, Taiwan
3.Natl Yang Ming Univ, Taipei Vet Gen Hosp, Dept Ophthalmol, Taipei 112, Taiwan
4.Beijing Union Med Coll Hosp, Dept Ophthalmol, Beijing, Peoples R China
5.Giridhar Eye Inst, Kochi, Kerala, India
6.Tokyo Womens Med Univ, Dept Ophthalmol, Tokyo, Japan
7.Fukushima Med Univ, Dept Ophthalmol, Fukushima, Japan
8.Tan Tock Seng Hosp, Natl Healthcare Grp Eye Inst, Singapore, Singapore
9.Rajavithi Hosp, Dept Ophthalmol, Bangkok, Thailand
10.Sankara Nethralaya, Madras, Tamil Nadu, India
11.Hallym Univ, Dept Ophthalmol, Kangnam Sacred Heart Hosp, Seoul, South Korea
12.Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Shatin, Hong Kong, Peoples R China
13.Catholic Univ Korea, Seoul St Marys Hosp, Dept Ophthalmol, Seoul, South Korea
14.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
15.Sun Yat Sen Univ, Zhong Shan Ophthalm Ctr, Guangzhou 510275, Guangdong, Peoples R China

Recommended Citation:
Koh, Adrian H. C.,Chen, Lee-Jen,Chen, Shih-Jen,et al. POLYPOIDAL CHOROIDAL VASCULOPATHY Evidence-Based Guidelines for Clinical Diagnosis and Treatment[J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,2013,33(4):686-716.
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