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Plasma soluble urokinase receptor levels are increased but do not distinguish primary from secondary focal segmental glomerulosclerosis
Huang, Jing1,2,3,4; Liu, Gang1,2,3,4; Zhang, Yi-Miao1,2,3,4; Cui, Zhao1,2,3,4; Wang, Fang1,2,3,4; Liu, Xiao-Jing1,2,3,4; Chu, Rong1,2,3,4; Chen, Ying1,2,3,4; Zhao, Ming-Hui1,2,3,4
关键词Focal Segmental Glomerulosclerosis (Fsgs) Nephrotic Syndrome Soluble Urokinase Receptor (Supar)
刊名KIDNEY INTERNATIONAL
2013-08-01
DOI10.1038/ki.2013.55
84期:2页:366-372
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]NEPHROTIC SYNDROME ; TUBULOINTERSTITIAL LESIONS ; REDUCES PROTEINURIA ; LUPUS NEPHRITIS ; PERMEABILITY ; EXPRESSION ; GLOMERULI ; VARIANTS ; UPAR ; FSGS
英文摘要

In this study, we measured soluble urokinase receptor levels, a possible permeability factor, in the plasma of patients with primary focal segmental glomerulosclerosis (FSGS) and determined their association with clinical and pathological data in 74 patients with primary FSGS. Healthy donors and patients with minimal change disease, membranous nephropathy, and secondary FSGS were used as controls. The plasma-soluble urokinase receptor levels, measured by commercial ELISA kits, of patients with primary FSGS (median: 2923, interquartile range 2205-4360 pg/ml) were significantly higher than those of patients with minimal change disease (median 2050 pg/ml), membranous nephropathy (median 2029 pg/ml), and normal individuals (median 1739 pg/ml). There was no significant difference in plasma-soluble urokinase receptor levels between the 74 patients with primary and 14 patients with secondary FSGS. The soluble urokinase receptor levels increased in the order of tip variant, to a not otherwise specified variant and a cellular variant. The soluble urokinase receptor levels were significantly but negatively correlated with creatinine clearance at presentation but positively correlated with crescent formation in patients with primary FSGS. During follow-up, receptor levels decreased significantly in patients with complete remission. Thus, plasma-soluble urokinase receptor levels did not differentiate primary and secondary FSGS, and although significantly elevated in FSGS, they showed considerable overlap with other glomerular diseases.

语种英语
WOS记录号WOS:000322517500021
项目编号2012CB517702 ; 81021004
资助机构Chinese 973 Project ; National Natural Science Foundation of China
引用统计
被引频次:52[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57532
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Univ First Hosp, Div Renal, Beijing 100034, Peoples R China
4.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China
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GB/T 7714
Huang, Jing,Liu, Gang,Zhang, Yi-Miao,et al. Plasma soluble urokinase receptor levels are increased but do not distinguish primary from secondary focal segmental glomerulosclerosis[J]. KIDNEY INTERNATIONAL,2013,84(2):366-372.
APA Huang, Jing.,Liu, Gang.,Zhang, Yi-Miao.,Cui, Zhao.,Wang, Fang.,...&Zhao, Ming-Hui.(2013).Plasma soluble urokinase receptor levels are increased but do not distinguish primary from secondary focal segmental glomerulosclerosis.KIDNEY INTERNATIONAL,84(2),366-372.
MLA Huang, Jing,et al."Plasma soluble urokinase receptor levels are increased but do not distinguish primary from secondary focal segmental glomerulosclerosis".KIDNEY INTERNATIONAL 84.2(2013):366-372.
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