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学科主题: 药学
题名:
Lanthanides enhance pulmonary absorption of insulin
作者: Shen, ZC; Cheng, Y; Zhang, Q; Wei, SL; Li, RC; Wang, K
关键词: lanthanide ions ; insulin ; pulmonary absorption ; bioavailability ; rat
刊名: BIOLOGICAL TRACE ELEMENT RESEARCH
发表日期: 2000-06-01
卷: 75, 期:1-3, 页:215-225
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]: HUMAN ERYTHROCYTE-MEMBRANE ; CONFORMATIONAL CHANGE ; PERMEABILITY ; TRANSPORT ; TERBIUM ; BINDING ; PROTEIN ; DOMAIN ; IONS ; LUNG
英文摘要:

Ln an effort to investigate the enhancement effect of lanthanide ions (Ln(3+)) on the absorption of larger molecules from the pulmonary pathway insulin (mol. wt. = 5730) was chosen as a model peptide. The absorption of insulin preadministered or coadministered with Ln(3+) from the lung was investigated by means of an in situ pulmonary absorption experiment. The enhancement absorption of insulin by Ln(3+) ions was evaluated by calculating the various bioavailabilities (Fr) of insulin from pulmonary absorption. Moreover, the temporal change of Gd content in serum was also investigated. Results showed that the promoting effect of Ln(3+) on the bioavailability of insulin is closely related to its species, concentration, and delivery order. The effect of the median Ln(3+) series was remarkably greater than that of Light and heavy Ln(3+). The anionic form of Gadolinium (Fr = 68.4%) seemed to be more effective compared with its cationic form (Fr = 59.5%). Coadministration of Gd3+ with insulin (Fr = 80.1%) was the most effective in increasing insulin absorption from the lung. Gd3+ was rapidly absorbed and metabolized to a normal level after 4 h. It was suggested that lanthanides in a very low concentration might become potent absorption enhancers to improve absorption of larger molecules via the pulmonary pathway.

语种: 英语
WOS记录号: WOS:000088128100021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57538
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Med Univ, Dept Pharm, Beijing 100083, Peoples R China
2.Beijing Med Univ, Dept Bioinorgan Chem & Inorgan Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Shen, ZC,Cheng, Y,Zhang, Q,et al. Lanthanides enhance pulmonary absorption of insulin[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2000,75(1-3):215-225.
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