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Lanthanides enhance pulmonary absorption of insulin
Shen, ZC; Cheng, Y; Zhang, Q; Wei, SL; Li, RC; Wang, K
关键词Lanthanide Ions Insulin Pulmonary Absorption Bioavailability Rat
刊名BIOLOGICAL TRACE ELEMENT RESEARCH
2000-06-01
75期:1-3页:215-225
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]HUMAN ERYTHROCYTE-MEMBRANE ; CONFORMATIONAL CHANGE ; PERMEABILITY ; TRANSPORT ; TERBIUM ; BINDING ; PROTEIN ; DOMAIN ; IONS ; LUNG
英文摘要

Ln an effort to investigate the enhancement effect of lanthanide ions (Ln(3+)) on the absorption of larger molecules from the pulmonary pathway insulin (mol. wt. = 5730) was chosen as a model peptide. The absorption of insulin preadministered or coadministered with Ln(3+) from the lung was investigated by means of an in situ pulmonary absorption experiment. The enhancement absorption of insulin by Ln(3+) ions was evaluated by calculating the various bioavailabilities (Fr) of insulin from pulmonary absorption. Moreover, the temporal change of Gd content in serum was also investigated. Results showed that the promoting effect of Ln(3+) on the bioavailability of insulin is closely related to its species, concentration, and delivery order. The effect of the median Ln(3+) series was remarkably greater than that of Light and heavy Ln(3+). The anionic form of Gadolinium (Fr = 68.4%) seemed to be more effective compared with its cationic form (Fr = 59.5%). Coadministration of Gd3+ with insulin (Fr = 80.1%) was the most effective in increasing insulin absorption from the lung. Gd3+ was rapidly absorbed and metabolized to a normal level after 4 h. It was suggested that lanthanides in a very low concentration might become potent absorption enhancers to improve absorption of larger molecules via the pulmonary pathway.

语种英语
WOS记录号WOS:000088128100021
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57538
专题北京大学药学院
作者单位1.Beijing Med Univ, Dept Pharm, Beijing 100083, Peoples R China
2.Beijing Med Univ, Dept Bioinorgan Chem & Inorgan Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Shen, ZC,Cheng, Y,Zhang, Q,et al. Lanthanides enhance pulmonary absorption of insulin[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2000,75(1-3):215-225.
APA Shen, ZC,Cheng, Y,Zhang, Q,Wei, SL,Li, RC,&Wang, K.(2000).Lanthanides enhance pulmonary absorption of insulin.BIOLOGICAL TRACE ELEMENT RESEARCH,75(1-3),215-225.
MLA Shen, ZC,et al."Lanthanides enhance pulmonary absorption of insulin".BIOLOGICAL TRACE ELEMENT RESEARCH 75.1-3(2000):215-225.
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