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Multicenter, Intra-individual Comparison of Single Dose Gadobenate Dimeglumine and Double Dose Gadopentetate Dimeglumine for MR Angiography of the Peripheral Arteries (the Peripheral VALUE Study)
Wang, Jian1; Yan, Fuhua2; Liu, Jianyu3; Lu, Jianping1; Li, Dan4; Luan, Jingyuan5; Wang, Xiaoying6; Li, Yuan7; Iezzi, Roberto8; De Cobelli, Francesco9
关键词Contrast-enhanced Mr Angiography Peripheral Arteries Gadolinium Contrast Agents Comparative Studies
刊名JOURNAL OF MAGNETIC RESONANCE IMAGING
2013-10-01
DOI10.1002/jmri.24040
38期:4页:926-937
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
资助者Bracco Diagnostics Inc., Princeton, N.J. ; Bracco Diagnostics Inc., Princeton, N.J.
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]MAGNETIC-RESONANCE ANGIOGRAPHY ; NEPHROGENIC SYSTEMIC FIBROSIS ; DIGITAL-SUBTRACTION-ANGIOGRAPHY ; AORTOILIAC OCCLUSIVE DISEASE ; CONTRAST AGENTS ; PHASE-III ; CONVENTIONAL ANGIOGRAPHY ; DIAGNOSTIC-ACCURACY ; LOWER-EXTREMITIES ; VASCULAR-DISEASE
英文摘要

PurposeTo prospectively compare single dose gadobenate dimeglumine with double dose gadopentetate dimeglumine for CE-MRA in patients with peripheral arterial occlusive disease (PAOD) using an intra-individual crossover study design in which all patients received both contrast agents in otherwise identical CE-MRA examinations.

Materials and MethodsInstitutional review board and regulatory approval were granted and all patients provided written informed consent. Sixty-eight patients (53M/15F; 62.4 15.7 years) with mild-to-severe PAOD were enrolled for randomized 3-station CE-MRA with 0.1 mmol/kg gadobenate dimeglumine and 0.2 mmol/kg gadopentetate dimeglumine. Three blinded readers assessed images for vessel anatomical delineation, disease detection/exclusion, and global preference. Diagnostic performance for detection of 51% stenosis was determined for 53 patients who underwent DSA. Noninferiority was assessed using the Wilcoxon Signed Rank, McNemar, and Wald tests. Quantitative enhancement was compared.

ResultsNo differences (P 0.25) were noted for any qualitative parameter at any station. Equivalence was reported in at least 62/64 patients (93.8% 3-reader agreement) for diagnostic preference. Superiority for gadobenate dimeglumine was reported by all readers for diagnostic performance (sensitivity: 80.4-88.0% versus 75.2-85.8%; specificity: 89.8-96.0% versus 88.7-94.8%; accuracy: 87.4-91.7% versus 84.9-90.6%; PPV: 84.0-92.8% versus 82.3-90.8%; NPV: 88.5-92.4% versus 85.7-91.1%). Quantitative enhancement was similar in the pelvis but significantly (P < 0.05) greater with gadobenate dimeglumine in the thigh for two readers.

ConclusionImage quality and diagnostic performance on peripheral CE-MRA with 0.1 mmol/kg gadobenate dimeglumine is at least equivalent to that with 0.2 mmol/kg gadopentetate dimeglumine. J. Magn. Reson. Imaging 2013;38:926-937. (c) 2013 Wiley Periodicals, Inc.

语种英语
所属项目编号MH-137
资助者Bracco Diagnostics Inc., Princeton, N.J. ; Bracco Diagnostics Inc., Princeton, N.J.
WOS记录号WOS:000328224900020
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57539
Collection北京大学第三临床医学院_放射科
作者单位1.Anhui Prov Hosp, Dept Med Imaging, Hefei, Anhui, Peoples R China
2.Shanghai Changhai Hosp, Dept Radiol, Shanghai, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Radiol, Shanghai 200025, Peoples R China
4.Peking Univ, Hosp 3, Dept Radiol, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 3, Dept Intervent Radiol & Vasc Surg, Beijing 100871, Peoples R China
6.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
7.Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200433, Peoples R China
8.Catholic Univ, A Gemelli Hosp, Inst Radiol, Dept Bioimaging & Radiol Sci, Rome, Italy
9.Univ Milan, Osped San Raffaele, UO Risonanza Magnet, I-20127 Milan, Italy
Recommended Citation
GB/T 7714
Wang, Jian,Yan, Fuhua,Liu, Jianyu,et al. Multicenter, Intra-individual Comparison of Single Dose Gadobenate Dimeglumine and Double Dose Gadopentetate Dimeglumine for MR Angiography of the Peripheral Arteries (the Peripheral VALUE Study)[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2013,38(4):926-937.
APA Wang, Jian.,Yan, Fuhua.,Liu, Jianyu.,Lu, Jianping.,Li, Dan.,...&De Cobelli, Francesco.(2013).Multicenter, Intra-individual Comparison of Single Dose Gadobenate Dimeglumine and Double Dose Gadopentetate Dimeglumine for MR Angiography of the Peripheral Arteries (the Peripheral VALUE Study).JOURNAL OF MAGNETIC RESONANCE IMAGING,38(4),926-937.
MLA Wang, Jian,et al."Multicenter, Intra-individual Comparison of Single Dose Gadobenate Dimeglumine and Double Dose Gadopentetate Dimeglumine for MR Angiography of the Peripheral Arteries (the Peripheral VALUE Study)".JOURNAL OF MAGNETIC RESONANCE IMAGING 38.4(2013):926-937.
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