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学科主题: 临床医学
题名:
Effect of endothelin-1 in esophageal squamous cell carcinoma invasion and its correlation with cathepsin B
作者: Jiao, Wen-Jie; Xu, Jing; Pan, Hao; Wang, Tian-You; Shen, Yi
关键词: esophageal tumor ; endothelin ; cathepsin ; invasion
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2007-08-07
卷: 13, 期:29, 页:4002-4005
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: EXTRACELLULAR CA2+ INFLUX ; BREAST-CANCER ; GROWTH-FACTOR ; A-RECEPTOR ; EXPRESSION ; ACTIVATION ; APOPTOSIS ; PROMOTES ; AMPLICON ; INVASIVENESS
英文摘要:

AIM: To investigate the effect of endothelin-1 in the invasion of esophageal cancer and determine whether cathepsin B plays a role in the course.

METHODS: Western blotting was employed to detect the expression of ET-1 protein in 75 samples of esophageal squamous cell cancer and matched normal esophageal mucosa. Bosentan, a dual ET (A/B)-receptor antagonist, was used to inhibit the binding of endothelin-1 and its receptors and cut down its biological role. In vitro matrigel invasion assays were made to show the invasive ability of esophageal cancer cells with and without bosentan. Subsequently, we evaluated cathepsin B activity and expression in EC9706 cell with and without bosentan.

RESULTS: We found 74.7% (56/75) tumors had an overexpression of ET-1 protein by Western blotting. Bosentan significantly inhibited matrigel invasion of cancer cells in vitro. EC9706 cells have a positive expression of cathepsin B protein, and bosentan can down-regulate its expression and activity.

CONCLUSION: Endothelin-1 may enhance the invasive ability of human esophageal cancer cells, and its role is correlated with cathepsin B. (c) 2007 WJG. All rights reserved.

语种: 英语
WOS记录号: WOS:000248546500016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57541
Appears in Collections:北京大学第一临床医学院_胸外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Thorac Surg, Beijing 100034, Peoples R China
2.Affiliated Hosp Qingdao Univ Med Coll, Comm Disciplinary Inspect, Dept Thorac Surg, Qingdao 266003, Shandong, Peoples R China
3.Beijing Friendship Hosp, Dept Thorac Surg, Beijing 100050, Peoples R China

Recommended Citation:
Jiao, Wen-Jie,Xu, Jing,Pan, Hao,et al. Effect of endothelin-1 in esophageal squamous cell carcinoma invasion and its correlation with cathepsin B[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2007,13(29):4002-4005.
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