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IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科  > 期刊论文
学科主题: 临床医学
题名:
Biological Effects of I-125 Seeds Radiation on A549 Lung Cancer Cells: G2/M Arrest and Enhanced Cell Death
作者: Qu, Ang1; Wang, Hao1; Li, Jinna1; Wang, Junjie1; Liu, Jingjia1; Hou, Yuzhu2; Huang, Li1; Zhao, Yong2
关键词: Lung cancer ; 125I continuous low dose rate radiation ; Single external beam radiation ; DNA double-strand breaks
刊名: CANCER INVESTIGATION
发表日期: 2014-07-01
DOI: 10.3109/07357907.2014.905585
卷: 32, 期:6, 页:209-217
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: DOUBLE-STRAND BREAK ; DEPENDENT PROTEIN-KINASE ; DNA-DAMAGE RESPONSE ; CATALYTIC SUBUNIT ; PROSTATE-CANCER ; REPAIR ; IMPLANTATION ; PKCS ; AUTOPHOSPHORYLATION ; PHOSPHORYLATION
英文摘要:

External beam radiation (EBRT) and I-125 seeds continuous low dose rate radiation (CLDR) were used to treat patients with lung cancer. We herein investigated the biological effects of EBRT and CLDR on lung cancer cells. A549 human lung cancer cell line was thus exposed to different doses of EBRT and CLDR. CLDR was more efficient to inhibit cell growth than EBRT. CLDR induced increased DNA damage as evidenced by long-lasting p-H2AX activity. The enhanced inhibitory effects of CLDR on lung cancer cell growth may be, at least in part, due to the increased Bax/Bcl2 ratio and cyclin B1-mediated G2/M arrest.

语种: 英语
WOS记录号: WOS:000337025900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57542
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Dept Radiat Oncol, Hosp 3, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China

Recommended Citation:
Qu, Ang,Wang, Hao,Li, Jinna,et al. Biological Effects of I-125 Seeds Radiation on A549 Lung Cancer Cells: G2/M Arrest and Enhanced Cell Death[J]. CANCER INVESTIGATION,2014,32(6):209-217.
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