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学科主题临床医学
Biological Effects of I-125 Seeds Radiation on A549 Lung Cancer Cells: G2/M Arrest and Enhanced Cell Death
Qu, Ang1; Wang, Hao1; Li, Jinna1; Wang, Junjie1; Liu, Jingjia1; Hou, Yuzhu2; Huang, Li1; Zhao, Yong2
关键词Lung Cancer 125i Continuous Low Dose Rate Radiation Single External Beam Radiation Dna Double-strand Breaks
刊名CANCER INVESTIGATION
2014-07-01
DOI10.3109/07357907.2014.905585
32期:6页:209-217
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]DOUBLE-STRAND BREAK ; DEPENDENT PROTEIN-KINASE ; DNA-DAMAGE RESPONSE ; CATALYTIC SUBUNIT ; PROSTATE-CANCER ; REPAIR ; IMPLANTATION ; PKCS ; AUTOPHOSPHORYLATION ; PHOSPHORYLATION
英文摘要

External beam radiation (EBRT) and I-125 seeds continuous low dose rate radiation (CLDR) were used to treat patients with lung cancer. We herein investigated the biological effects of EBRT and CLDR on lung cancer cells. A549 human lung cancer cell line was thus exposed to different doses of EBRT and CLDR. CLDR was more efficient to inhibit cell growth than EBRT. CLDR induced increased DNA damage as evidenced by long-lasting p-H2AX activity. The enhanced inhibitory effects of CLDR on lung cancer cell growth may be, at least in part, due to the increased Bax/Bcl2 ratio and cyclin B1-mediated G2/M arrest.

语种英语
WOS记录号WOS:000337025900001
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57542
专题北京大学第三临床医学院_肿瘤放疗科
北京大学第二临床医学院_肝病科
北京大学第三临床医学院_肿瘤治疗中心
作者单位1.Peking Univ, Dept Radiat Oncol, Hosp 3, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Qu, Ang,Wang, Hao,Li, Jinna,et al. Biological Effects of I-125 Seeds Radiation on A549 Lung Cancer Cells: G2/M Arrest and Enhanced Cell Death[J]. CANCER INVESTIGATION,2014,32(6):209-217.
APA Qu, Ang.,Wang, Hao.,Li, Jinna.,Wang, Junjie.,Liu, Jingjia.,...&Zhao, Yong.(2014).Biological Effects of I-125 Seeds Radiation on A549 Lung Cancer Cells: G2/M Arrest and Enhanced Cell Death.CANCER INVESTIGATION,32(6),209-217.
MLA Qu, Ang,et al."Biological Effects of I-125 Seeds Radiation on A549 Lung Cancer Cells: G2/M Arrest and Enhanced Cell Death".CANCER INVESTIGATION 32.6(2014):209-217.
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