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学科主题: 药物依赖
题名:
Assessing Cue-Induced Brain Response as a Function of Abstinence Duration in Heroin-Dependent Individuals: An Event-Related fMRI Study
作者: Li, Qiang1; Wang, Yarong1; Zhang, Yi2; Li, Wei1; Zhu, Jia1; Zheng, Ying1; Chen, Jiajie1; Zhao, Liyan3; Zhou, Zhenyu5; Liu, Yijun4,5; Wang, Wei1; Tian, Jie1,2,6
刊名: PLOS ONE
发表日期: 2013-05-07
DOI: 10.1371/journal.pone.0062911
卷: 8, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MEDIAL FRONTAL-CORTEX ; NEURAL RESPONSES ; MOTOR IMAGERY ; SMOKING CUES ; ADDICTION ; WITHDRAWAL ; TIME ; ORGANIZATION ; CONSUMPTION ; DYSFUNCTION
英文摘要:

The brain activity induced by heroin-related cues may play a role in the maintenance of heroin dependence. Whether the reinforcement or processing biases construct an everlasting feature of heroin addiction remains to be resolved. We used an event-related fMRI paradigm to measure brain activation in response to heroin cue-related pictures versus neutral pictures as the control condition in heroin-dependent patients undergoing short-term and long-term abstinence. The self-reported craving scores were significantly increased after cue exposure in the short-term abstinent patients (t = 3.000, P = 0.008), but no increase was found in the long-term abstinent patients (t = 1.510, P = 0.149). However, no significant differences in cue-induced craving changes were found between the two groups (t = 1.193, P = 0.850). Comparing between the long-term abstinence and short-term abstinence groups, significant decreases in brain activation were detected in the bilateral anterior cingulated cortex, left medial prefrontal cortex, caudate, middle occipital gyrus, inferior parietal lobule and right precuneus. Among all of the heroin dependent patients, the abstinence duration was negatively correlated with brain activation in the left medial prefrontal cortex and left inferior parietal lobule. These findings suggest that long-term abstinence may be useful for heroin-dependent patients to diminish their saliency value of heroin-related cues and possibly lower the relapse vulnerability to some extent.

语种: 英语
所属项目编号: 81201081 ; 81071142 ; 81071143 ; 60901064 ; 2008K12-02 ; 2009K01-65 ; 2010K16-03-01 ; 2010K16-03-02
项目资助者: National Natural Science Foundation of China ; Development Project of Science and Technology of Shaanxi Province
WOS记录号: WOS:000319654700080
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57544
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
3.Fourth Mil Med Univ, Dept Radiol, Tangdu Hosp, Xian 710032, Peoples R China
4.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian, Peoples R China
5.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
6.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32611 USA

Recommended Citation:
Li, Qiang,Wang, Yarong,Zhang, Yi,et al. Assessing Cue-Induced Brain Response as a Function of Abstinence Duration in Heroin-Dependent Individuals: An Event-Related fMRI Study[J]. PLOS ONE,2013,8(5).
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