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学科主题: 临床医学
题名:
Correlation Between Hyaluronic Acid, Hyaluronic Acid Synthase And Human Renal Clear Cell Carcinoma
作者: Cai, Jian-liang1; Li, Ming2; Na, Yan-qun1
关键词: Renal clear cell carcinoma ; Hyaluronic acid ; Hyaluronic acid synthase ; Gene
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2011-03-01
DOI: 10.1007/s11670-011-0059-6
卷: 23, 期:1, 页:59-63
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: EXPRESSION ; KIDNEY ; CD44 ; SIZE
英文摘要:

Objective: To study the correlation between hyaluronic acid (HA), hyaluronic acid synthase (HAS) and human renal clear cell carcinoma (RCCC).

Methods: The expression of three HAS isoforms′ gene and HA in 93 RCCC tissues, 27 nephridial tissues by the side of RCCC from two hospitals were measured with Real-Time RT-PCR. Western Blot and immunohistochemical methods and analyzed.

Results: All RCCC and adjacent normal tissues expressed three HASs′ mRNA & protein; at the mRNA level, both RCCC and adjacent normal tissues, expressed more HAS3 than HAS1 or HAS2, their differences were statistically significant (all P values <0.05); but, at the protein level, all HAS isoforms presented the equivalent expression. Compared with the adjacent non-neoplastic kidney tissues, the expression of all HAS isoforms′ mRNA in RCCC tissues were increased evidently and their differences were significant (all P values <0.0001); but at the protein level, only the expression of HAS3 increased evidently (P=0.022). In all adjacent normal tissues, more than 80% renal tubular cells strongly expressed HA, however, only the minority RCCC cases (16/93) presented weakly positive HA staining in few cancer nests (5%-30%), the difference were significant (P<0.0001). In RCCC tissues subgrouped according to clinical stage, pathological grade, lymphatic metastasis or not and distant metastasis or not, the HASs′ mRNA & protein differential expression all had no statistical significance (all P values >0.05).

Conclusion: Different from other malignancy, HA and HASs (except for HAS3) may not play important roles in the biological progress of human RCCC.

语种: 英语
WOS记录号: WOS:000290804200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57552
Appears in Collections:北京大学首钢医院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Shougang Hosp, Wu Jieping Urol Ctr, Beijing 100144, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Urol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Cai, Jian-liang,Li, Ming,Na, Yan-qun. Correlation Between Hyaluronic Acid, Hyaluronic Acid Synthase And Human Renal Clear Cell Carcinoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2011,23(1):59-63.
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