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学科主题: 基础医学
题名:
Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on lps-induced mesenteric microcirculatory disturbance in rats
作者: Guo, Jun1,3; Sun, Kai1; Wang, Chuan-She1,2; Fang, Su-Ping1; Horie, Yoshinori3; Yang, Ji-Ying1; Liu, Yu-Ying1; Wang, Fang1; Liu, Lian-Y1; Fan, Jing-Yu1; Hibi, Toshifurni3; Han, Jing. -Yan1,2,3
关键词: Salvia miltiorrhiza ; antioxidants ; microcirculation ; leukocyte adhesion ; mast cell degranulation
刊名: SHOCK
发表日期: 2008-02-01
DOI: 10.1097/SHK.0b013e318070c61a
卷: 29, 期:2, 页:205-211
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine ; Hematology ; Surgery ; Peripheral Vascular Disease
研究领域[WOS]: General & Internal Medicine ; Hematology ; Surgery ; Cardiovascular System & Cardiology
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; ADHESION MOLECULE EXPRESSION ; MURINE MAST-CELLS ; FACTOR-KAPPA-B ; ENDOTHELIAL-CELLS ; MICROVASCULAR DYSFUNCTION ; HYDROGEN-PEROXIDE ; ACTIVATION ; LIPOPOLYSACCHARIDE ; MILTIORRHIZA
英文摘要:

Salvia miltiorrhiza is a Chinese medicine widely used for treatment of various cardiovascular diseases. However, little is known about the role of dihydroxylphenyl lactic acid (DLA) and salvianolic acid B (SAB), the main ingredients of S. miltiorrhiza, in the microcirculation. This study aimed to investigate the effect of DLA and SAB on LPS-elicited microcirculatory disturbance, focusing especially on leukocyte adhesion and its potential mechanism. Mesenteric venular diameter, velocity of red blood cells in venules, shear rate of the venular wall, numbers of leukocytes adherent to and emigrated across the venular wall, and mast cell degranulation were determined by an inverted microscope in rats after LPS infusion with or without DLA or SAB. Expression of CD11 b and CD18 and production of superoxide anion (O-2-) and hydrogen peroxide (H2O2) by neutrophils were evaluated in vitro by flow cytometry. LPS exposure induced a significant increase in the number of adherent and emigrated leukocytes and mast cell degranulation, and a prominent decrease in the velocity of red blood cells in venules and shear rate of the venular wall. Additionally, in vitro experiments revealed an apparent enhancement in expression of CD1 1b and CD18 and production of O-2- and H2O2 by rat neutrophils by LPS stimulation. Treatment with DLA or SAB significantly ameliorated LPS-induced microcirculatory disturbance in rat mesentery and inhibited both the expression of CD11b and CD18 and the production of center dot O-2- and H2O2 by neutrophils caused by LPS.

语种: 英语
WOS记录号: WOS:000252733500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57555
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China
2.Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
3.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100871, Peoples R China

Recommended Citation:
Guo, Jun,Sun, Kai,Wang, Chuan-She,et al. Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on lps-induced mesenteric microcirculatory disturbance in rats[J]. SHOCK,2008,29(2):205-211.
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