学科主题基础医学
Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on lps-induced mesenteric microcirculatory disturbance in rats
Guo, Jun1,3; Sun, Kai1; Wang, Chuan-She1,2; Fang, Su-Ping1; Horie, Yoshinori3; Yang, Ji-Ying1; Liu, Yu-Ying1; Wang, Fang1; Liu, Lian-Y1; Fan, Jing-Yu1; Hibi, Toshifurni3; Han, Jing. -Yan1,2,3
关键词Salvia Miltiorrhiza Antioxidants Microcirculation Leukocyte Adhesion Mast Cell Degranulation
刊名SHOCK
2008-02-01
DOI10.1097/SHK.0b013e318070c61a
29期:2页:205-211
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Critical Care Medicine ; Hematology ; Surgery ; Peripheral Vascular Disease
研究领域[WOS]General & Internal Medicine ; Hematology ; Surgery ; Cardiovascular System & Cardiology
关键词[WOS]NECROSIS-FACTOR-ALPHA ; ADHESION MOLECULE EXPRESSION ; MURINE MAST-CELLS ; FACTOR-KAPPA-B ; ENDOTHELIAL-CELLS ; MICROVASCULAR DYSFUNCTION ; HYDROGEN-PEROXIDE ; ACTIVATION ; LIPOPOLYSACCHARIDE ; MILTIORRHIZA
英文摘要

Salvia miltiorrhiza is a Chinese medicine widely used for treatment of various cardiovascular diseases. However, little is known about the role of dihydroxylphenyl lactic acid (DLA) and salvianolic acid B (SAB), the main ingredients of S. miltiorrhiza, in the microcirculation. This study aimed to investigate the effect of DLA and SAB on LPS-elicited microcirculatory disturbance, focusing especially on leukocyte adhesion and its potential mechanism. Mesenteric venular diameter, velocity of red blood cells in venules, shear rate of the venular wall, numbers of leukocytes adherent to and emigrated across the venular wall, and mast cell degranulation were determined by an inverted microscope in rats after LPS infusion with or without DLA or SAB. Expression of CD11 b and CD18 and production of superoxide anion (O-2-) and hydrogen peroxide (H2O2) by neutrophils were evaluated in vitro by flow cytometry. LPS exposure induced a significant increase in the number of adherent and emigrated leukocytes and mast cell degranulation, and a prominent decrease in the velocity of red blood cells in venules and shear rate of the venular wall. Additionally, in vitro experiments revealed an apparent enhancement in expression of CD1 1b and CD18 and production of O-2- and H2O2 by rat neutrophils by LPS stimulation. Treatment with DLA or SAB significantly ameliorated LPS-induced microcirculatory disturbance in rat mesentery and inhibited both the expression of CD11b and CD18 and the production of center dot O-2- and H2O2 by neutrophils caused by LPS.

语种英语
WOS记录号WOS:000252733500009
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57555
Collection北京大学基础医学院_北大医学部天士力微循环研究中心
作者单位1.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China
2.Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
3.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Guo, Jun,Sun, Kai,Wang, Chuan-She,et al. Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on lps-induced mesenteric microcirculatory disturbance in rats[J]. SHOCK,2008,29(2):205-211.
APA Guo, Jun.,Sun, Kai.,Wang, Chuan-She.,Fang, Su-Ping.,Horie, Yoshinori.,...&Han, Jing. -Yan.(2008).Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on lps-induced mesenteric microcirculatory disturbance in rats.SHOCK,29(2),205-211.
MLA Guo, Jun,et al."Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on lps-induced mesenteric microcirculatory disturbance in rats".SHOCK 29.2(2008):205-211.
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