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学科主题: 药学
题名:
Asymmetric Total Synthesis of (+)-Dragmacidin D Reveals Unexpected Stereocomplexity
作者: Zhang, Fengying1; Wang, Bin1; Prasad, Pritesh3; Capon, Robert J.3; Jia, Yanxing1,2
刊名: ORGANIC LETTERS
发表日期: 2015-03-20
DOI: 10.1021/acs.orglett.5b00327
卷: 17, 期:6, 页:1529-1532
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: CYCLOHEPTANNELATED INDOLE FRAGMENT ; ENANTIOSELECTIVE TOTAL-SYNTHESIS ; EFFICIENT TOTAL-SYNTHESIS ; DRAGMACIDIN-E SYNTHESIS ; WATER MARINE SPONGE ; (+)-LYSERGIC ACID ; CLAVICIPITIC ACID ; DIRECT ANNULATION ; (+/-)-SEROTOBENINE ; SPONGOSORITES
英文摘要:

The first asymmetric total synthesis of the bis-indole marine alkaloid (+)-dragmacidin D (1) has been achieved. This synthesis revises an earlier configurational assignment based on biosynthetic considerations and assigns an R absolute configuration to (+)-1. The current studies reveal that natural dragmacidin D is isolated as either a racemate or a scalemic mixture (39% ee).

语种: 英语
所属项目编号: 21290183 ; 20120001110100 ; DP120100183
项目资助者: National Natural Science Foundation of China ; Ph.D. Programs Foundation of Ministry of Education of China ; State Key Laboratory of Drug Research, the Australian Research Council ; University of Queensland, Institute for Molecular Bioscience
WOS记录号: WOS:000351558100046
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57557
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Recommended Citation:
Zhang, Fengying,Wang, Bin,Prasad, Pritesh,et al. Asymmetric Total Synthesis of (+)-Dragmacidin D Reveals Unexpected Stereocomplexity[J]. ORGANIC LETTERS,2015,17(6):1529-1532.
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