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KH902, a Recombinant Human VEGF Receptor Fusion Protein, Reduced the Level of Placental Growth Factor in Alkali Burn Induced-Corneal Neovascularization
Zhou, Ai-Yi; Bai, Yu-Jing; Zhao, Min; Yu, Wen-Zhen; Li, Xiao-Xin
关键词Corneal Neovascularization Kh902 Placental Growth Factor Vascular Endothelial Growth Factor New Vessels Regression
刊名OPHTHALMIC RESEARCH
2013
DOI10.1159/000353437
50期:3页:180-186
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]ANTI-ANGIOGENIC THERAPY ; BEVACIZUMAB ; SUBCONJUNCTIVAL ; INFLAMMATION ; INHIBITION ; EFFICACY ; MODEL ; PLGF
英文摘要

Aims: To investigate the expression of placental growth factor (PIGF) in alkali burn-induced murine corneal neovascularization (NV); to evaluate the effects of KH902, a vascular endothelial growth factor receptor decoy, on prevention and regression of new vessels growths in the cornea; and to determine the influence of KH902 on the levels of vascular endothelial growth factor (VEGF) and PIGF in alkali burn-induced corneal NV. Methods: Mouse corneal NV was induced by alkali burn. The expression of PIGF was detected by immunohistochemistry and reverse-transcription polymerase chain reaction (RT-PCR). To evaluate the effects of KH902, corneal NV was observed and photographed every 3 days for a total of 28 days after the alkali burn. The percentage of NV area was measured and compared with that of the control group. The VEGF and PIGF levels in the cornea were evaluated by enzyme linked innmunosorbent assay (ELISA). Results: PIGF was expressed during the alkali burn-induced corneal neovascularization. On day 3 (D3), day 6 (D6) and day 9 (D9) after chemical cauterization, the length of the longest new vessel and the neovascularization areas in the KH902-treated groups were significantly smaller than those of the PBS-treated group (p < 0.05). The areas of established corneal NV of the KH902-treated groups regressed with time, but the control groups showed no natural regression. The VEGF and PIGF levels of the cornea in the treated groups were significantly decreased compared to those of the control group (p < 0.05). Conclusions: PIGF may be involved in alkali burn-induced corneal NV. KH902 significantly inhibited new vessel growth and promoted the regression of established vessels in a mouse model of corneal NV, and it also reduced the levels of VEGF and PIGF in the cornea. Copyright (c) 2013 S. Karger AG, Basel

语种英语
WOS记录号WOS:000324783800007
项目编号2011CB510200
资助机构National Basic Research Program of China (973 Program)
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57560
专题北京大学第二临床医学院
北京大学第二临床医学院_眼科
作者单位Peking Univ, Peoples Hosp, Minist Educ, Dept Ophthalmol,Key Lab Vis Loss & Restorat, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Ai-Yi,Bai, Yu-Jing,Zhao, Min,et al. KH902, a Recombinant Human VEGF Receptor Fusion Protein, Reduced the Level of Placental Growth Factor in Alkali Burn Induced-Corneal Neovascularization[J]. OPHTHALMIC RESEARCH,2013,50(3):180-186.
APA Zhou, Ai-Yi,Bai, Yu-Jing,Zhao, Min,Yu, Wen-Zhen,&Li, Xiao-Xin.(2013).KH902, a Recombinant Human VEGF Receptor Fusion Protein, Reduced the Level of Placental Growth Factor in Alkali Burn Induced-Corneal Neovascularization.OPHTHALMIC RESEARCH,50(3),180-186.
MLA Zhou, Ai-Yi,et al."KH902, a Recombinant Human VEGF Receptor Fusion Protein, Reduced the Level of Placental Growth Factor in Alkali Burn Induced-Corneal Neovascularization".OPHTHALMIC RESEARCH 50.3(2013):180-186.
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