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学科主题: 临床医学
题名:
KH902, a Recombinant Human VEGF Receptor Fusion Protein, Reduced the Level of Placental Growth Factor in Alkali Burn Induced-Corneal Neovascularization
作者: Zhou, Ai-Yi; Bai, Yu-Jing; Zhao, Min; Yu, Wen-Zhen; Li, Xiao-Xin
关键词: Corneal neovascularization ; KH902 ; Placental growth factor ; Vascular endothelial growth factor ; New vessels regression
刊名: OPHTHALMIC RESEARCH
发表日期: 2013
DOI: 10.1159/000353437
卷: 50, 期:3, 页:180-186
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: ANTI-ANGIOGENIC THERAPY ; BEVACIZUMAB ; SUBCONJUNCTIVAL ; INFLAMMATION ; INHIBITION ; EFFICACY ; MODEL ; PLGF
英文摘要:

Aims: To investigate the expression of placental growth factor (PIGF) in alkali burn-induced murine corneal neovascularization (NV); to evaluate the effects of KH902, a vascular endothelial growth factor receptor decoy, on prevention and regression of new vessels growths in the cornea; and to determine the influence of KH902 on the levels of vascular endothelial growth factor (VEGF) and PIGF in alkali burn-induced corneal NV. Methods: Mouse corneal NV was induced by alkali burn. The expression of PIGF was detected by immunohistochemistry and reverse-transcription polymerase chain reaction (RT-PCR). To evaluate the effects of KH902, corneal NV was observed and photographed every 3 days for a total of 28 days after the alkali burn. The percentage of NV area was measured and compared with that of the control group. The VEGF and PIGF levels in the cornea were evaluated by enzyme linked innmunosorbent assay (ELISA). Results: PIGF was expressed during the alkali burn-induced corneal neovascularization. On day 3 (D3), day 6 (D6) and day 9 (D9) after chemical cauterization, the length of the longest new vessel and the neovascularization areas in the KH902-treated groups were significantly smaller than those of the PBS-treated group (p < 0.05). The areas of established corneal NV of the KH902-treated groups regressed with time, but the control groups showed no natural regression. The VEGF and PIGF levels of the cornea in the treated groups were significantly decreased compared to those of the control group (p < 0.05). Conclusions: PIGF may be involved in alkali burn-induced corneal NV. KH902 significantly inhibited new vessel growth and promoted the regression of established vessels in a mouse model of corneal NV, and it also reduced the levels of VEGF and PIGF in the cornea. Copyright (c) 2013 S. Karger AG, Basel

语种: 英语
所属项目编号: 2011CB510200
项目资助者: National Basic Research Program of China (973 Program)
WOS记录号: WOS:000324783800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57560
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Minist Educ, Dept Ophthalmol,Key Lab Vis Loss & Restorat, Beijing 100044, Peoples R China

Recommended Citation:
Zhou, Ai-Yi,Bai, Yu-Jing,Zhao, Min,et al. KH902, a Recombinant Human VEGF Receptor Fusion Protein, Reduced the Level of Placental Growth Factor in Alkali Burn Induced-Corneal Neovascularization[J]. OPHTHALMIC RESEARCH,2013,50(3):180-186.
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