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学科主题: 药学
题名:
In Vivo Evaluation of Silybin Nanosuspensions Targeting Liver
作者: Wang, Yancai1; Wang, Lianqin2; Liu, Zhaoping3; Zhang, Dianrui3; Zhang, Qiang4
关键词: Silybin ; Nanosuspensions ; Biodistribution ; Pharmacodynamics ; Targeting Delivery
刊名: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
发表日期: 2012-10-01
DOI: 10.1166/jbn.2012.1444
卷: 8, 期:5, 页:760-769
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Medicine, Research & Experimental
研究领域[WOS]: Science & Technology - Other Topics ; Research & Experimental Medicine
关键词[WOS]: LIPID NANOPARTICLES ; TISSUE DISTRIBUTION ; DRUG NANOCRYSTALS ; RAT-LIVER ; DELIVERY ; DAMAGE ; INHIBITION ; PHARMACOKINETICS ; DIHEMISUCCINATE ; BIOAVAILABILITY
英文摘要:

The present study investigated the production, in vivo biodistribution and hepatoprotective of two formulated silybin nanosuspensions with different particle size. The physicochemical properties of the two formulated silybin nanosuspensions were investigated by TEM, AFM and SEM. A kinetic study was conducted to evaluate the influence of particle size on the in vivo tissue distribution following intravenous administration in the mice. The in vivo hepatoprotective studies were conducted on beagle dogs with optimized setting. A clear physicochemical difference was observed among the silybin solution, larger particles and the small particles. The formulation of larger particle size was preferentially targeted at liver and spleen. The silybin nanosuspensions, administrated either intravenously or orally, presented significant (P <= 0.05) hepatoprotective effect by reducing the serum marker enzymes such as AST, ALT, ALP, TBIL and GGT. Histopathological study further confirmed the hepatoprotective activity of the two silybin nanosuspensions formulations when compared with the CCl4 treated control group. These results indicate that the nanosuspensions approaches could be used to improve the drug target delivery and therapeutic efficacy of the silybin.

语种: 英语
所属项目编号: 2009CB930300 ; 2009ZX09502-001
项目资助者: National Basic Research Program of China (973 Program) ; technological specialized project for Significant New Formulation of New Drugs
WOS记录号: WOS:000306941400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57561
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Polytech Univ, Sch Chem & Pharmaceut Engn, Jinan 250353, Peoples R China
2.Hosp Shandong Polytech Univ, Jinan 250353, Peoples R China
3.Shandong Univ, Coll Pharm, Jinan 250012, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Yancai,Wang, Lianqin,Liu, Zhaoping,et al. In Vivo Evaluation of Silybin Nanosuspensions Targeting Liver[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2012,8(5):760-769.
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