IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
A quantification model for apoptosis in mouse embryos in the early stage of fetation
Wang PengFei1; Fu JianHua1; Ma WanYun1; Chen DieYan1; Lue DanYu2; Bai WenJia3
关键词Apoptosis Preimplantation Mouse Embryo Tplsm Quantification Model
刊名SCIENCE IN CHINA SERIES C-LIFE SCIENCES
2009-10-01
DOI10.1007/s11427-009-0130-4
52期:10页:922-927
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology
资助者National Key Basic Research Program of China ; National Natural Science Foundation of China ; Chinese Ministry of Education ; National Key Basic Research Program of China ; National Natural Science Foundation of China ; Chinese Ministry of Education
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
关键词[WOS]CELL-DEATH ; PREIMPLANTATION EMBRYOS ; BLASTOCYST ; EXPRESSION ; SURVIVAL
英文摘要

Apoptosis is the most important inducement and modulator for embryos in the early stage of fetation, i.e. after the 8-cell stage, mostly the morula and blastula stage, to proceed to the stage of nonlinear development. Using a two-photon laser scanning microscopy (TPLSM) system, we obtained 3-dimensional (M) fluorescent images of preimplantation mouse embryos. A model for quantification was established. The statistical results for the spatial location of apoptosis bodies in embryos was obtained following image processing, as well as investigation of the kinetics of apoptosis. It was found that most (70%) apoptosis occurred in the trophectoderm, and the departure between the centroid and geometric center of embryos had a step transition when embryos developed into the 32-cell stage, which was consistent with the theoretical prediction that the blastocele would induce a symmetry break of the distribution of cells in embryos.

语种英语
所属项目编号2007CB5119004 ; 90919012 ; 10874099 ; 306020
资助者National Key Basic Research Program of China ; National Natural Science Foundation of China ; Chinese Ministry of Education ; National Key Basic Research Program of China ; National Natural Science Foundation of China ; Chinese Ministry of Education
WOS记录号WOS:000271718700004
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57564
Collection北京大学基础医学院
作者单位1.Tsinghua Univ, Dept Phys, Educ Minist, Key Lab Atom & Mol Nanosci, Beijing 100084, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Anat & Histol & Embryol, Beijing 100083, Peoples R China
3.Tsinghua Univ, Dept Automat, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Wang PengFei,Fu JianHua,Ma WanYun,et al. A quantification model for apoptosis in mouse embryos in the early stage of fetation[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2009,52(10):922-927.
APA Wang PengFei,Fu JianHua,Ma WanYun,Chen DieYan,Lue DanYu,&Bai WenJia.(2009).A quantification model for apoptosis in mouse embryos in the early stage of fetation.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,52(10),922-927.
MLA Wang PengFei,et al."A quantification model for apoptosis in mouse embryos in the early stage of fetation".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 52.10(2009):922-927.
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