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Nanofibrous Scaffold Prepared by Electrospinning of Poly(vinyl alcohol)/Gelatin Aqueous Solutions
Yang, Chao1,2,3; Wu, Xiaomian2; Zhao, Yinghui2; Xu, Ling1,2; Wei, Shicheng2,4
关键词Electrospinning Pva Gelatin Nanofiber Scaffold
刊名JOURNAL OF APPLIED POLYMER SCIENCE
2011-09-05
DOI10.1002/app.33934
121期:5页:3047-3055
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]NORMAL HUMAN KERATINOCYTES ; GELATIN NANOFIBERS ; SKIN ; COLLAGEN ; MORPHOLOGY ; MEMBRANE ; DELIVERY ; BEHAVIOR
英文摘要

A series of nanofibrous scaffolds were prepared by electrospinning of poly(vinyl alcohol) (PVA)/gelatin aqueous solution. PVA and gelatin was dissolved in pure water and blended in full range, then being electrospun to prepared nanofibers, followed by being crosslinked with glutaraldehyde vapor and heat treatment to form nanofibrous scaffold. Field emission scanning electron microscope (FESEM) images of the nanofibers manifested that the fiber average diameters decreased from 290 to 90 nm with the increasing of gelatin. In vitro degradation rates of the nanofibers were also correlated with the composition and physical properties of electrospinning solutions. Cytocompatibility of the scaffolds was evaluated by cells morphology and MTT assay. The FESEM images revealed that NIH 3T3 fibroblasts spread and elongated actively on the scaffolds with spindle-like and star-type shape. The results of cell attachment and proliferation on the nanofibrous scaffolds suggested that the cytotoxicity of all samples are grade 1 or grade 0, indicating that the material had sound biosafety as biomaterials. Compared with pure PVA and gelatin scaffolds, the hybrid ones possess improved biocompatibility and controllability. These results indicate that the PVA/gelatin nanofibrous have potential as skin scaffolds or wound dressing. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 3047-3055, 2011

语种英语
WOS记录号WOS:000291598100068
项目编号2007CB936103 ; PKUJC2009001
资助机构Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; State Key Development Program for Basic Research of China ; Peking University Interdisciplinary and Emerging Disciplines Research Foundation
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57565
专题北京大学口腔医学院
北京大学第一临床医学院_肿瘤化疗科
北京大学临床肿瘤学院_口腔科
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Sch Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Appl Linguist, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Chao,Wu, Xiaomian,Zhao, Yinghui,et al. Nanofibrous Scaffold Prepared by Electrospinning of Poly(vinyl alcohol)/Gelatin Aqueous Solutions[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2011,121(5):3047-3055.
APA Yang, Chao,Wu, Xiaomian,Zhao, Yinghui,Xu, Ling,&Wei, Shicheng.(2011).Nanofibrous Scaffold Prepared by Electrospinning of Poly(vinyl alcohol)/Gelatin Aqueous Solutions.JOURNAL OF APPLIED POLYMER SCIENCE,121(5),3047-3055.
MLA Yang, Chao,et al."Nanofibrous Scaffold Prepared by Electrospinning of Poly(vinyl alcohol)/Gelatin Aqueous Solutions".JOURNAL OF APPLIED POLYMER SCIENCE 121.5(2011):3047-3055.
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