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学科主题: 口腔医学
题名:
Nanofibrous Scaffold Prepared by Electrospinning of Poly(vinyl alcohol)/Gelatin Aqueous Solutions
作者: Yang, Chao1,2,3; Wu, Xiaomian2; Zhao, Yinghui2; Xu, Ling1,2; Wei, Shicheng2,4
关键词: electrospinning ; PVA ; gelatin ; nanofiber ; scaffold
刊名: JOURNAL OF APPLIED POLYMER SCIENCE
发表日期: 2011-09-05
DOI: 10.1002/app.33934
卷: 121, 期:5, 页:3047-3055
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Polymer Science
研究领域[WOS]: Polymer Science
关键词[WOS]: NORMAL HUMAN KERATINOCYTES ; GELATIN NANOFIBERS ; SKIN ; COLLAGEN ; MORPHOLOGY ; MEMBRANE ; DELIVERY ; BEHAVIOR
英文摘要:

A series of nanofibrous scaffolds were prepared by electrospinning of poly(vinyl alcohol) (PVA)/gelatin aqueous solution. PVA and gelatin was dissolved in pure water and blended in full range, then being electrospun to prepared nanofibers, followed by being crosslinked with glutaraldehyde vapor and heat treatment to form nanofibrous scaffold. Field emission scanning electron microscope (FESEM) images of the nanofibers manifested that the fiber average diameters decreased from 290 to 90 nm with the increasing of gelatin. In vitro degradation rates of the nanofibers were also correlated with the composition and physical properties of electrospinning solutions. Cytocompatibility of the scaffolds was evaluated by cells morphology and MTT assay. The FESEM images revealed that NIH 3T3 fibroblasts spread and elongated actively on the scaffolds with spindle-like and star-type shape. The results of cell attachment and proliferation on the nanofibrous scaffolds suggested that the cytotoxicity of all samples are grade 1 or grade 0, indicating that the material had sound biosafety as biomaterials. Compared with pure PVA and gelatin scaffolds, the hybrid ones possess improved biocompatibility and controllability. These results indicate that the PVA/gelatin nanofibrous have potential as skin scaffolds or wound dressing. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 3047-3055, 2011

语种: 英语
所属项目编号: 2007CB936103 ; PKUJC2009001
项目资助者: Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; State Key Development Program for Basic Research of China ; Peking University Interdisciplinary and Emerging Disciplines Research Foundation
WOS记录号: WOS:000291598100068
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57565
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Sch Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Appl Linguist, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Chao,Wu, Xiaomian,Zhao, Yinghui,et al. Nanofibrous Scaffold Prepared by Electrospinning of Poly(vinyl alcohol)/Gelatin Aqueous Solutions[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2011,121(5):3047-3055.
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