北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学血液病研究所  > 期刊论文
学科主题: 临床医学
题名:
High frequencies of CD62L(+) naive regulatory T cells in allografts are associated with a low risk of acute graft-versus-host disease following unmanipulated allogeneic haematopoietic stem cell transplantation
作者: Lu, S-Y.; Liu, K-Y.; Liu, D-H.; Xu, L-P.; Huang, X-J.1
关键词: acute graft-versus-host disease ; allogeneic haematopoietic stem cell transplantation ; immune reconstitution ; immune tolerance ; regulatory T cell
刊名: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
发表日期: 2011-08-01
DOI: 10.1111/j.1365-2249.2011.04418.x
卷: 165, 期:2, 页:264-277
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: IDENTICAL SIBLING TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; IN-VITRO ; PERIPHERAL-BLOOD ; CUTTING EDGE ; CD4(+)CD25(+) ; GVHD ; TOLERANCE ; IMPACT ; VIVO
英文摘要:

Regulatory T cells (T-regs) play a key role in the prevention of acute graft-versus-host disease (aGVHD). To investigate the association between T-reg subsets and aGVHD, we prospectively analysed T cell subsets in the allografts of 35 patients undergoing myeloablative unmanipulated haematopoietic stem cell transplantation. Multivariate analysis found that patients infused with less than 0.29 10(6)/kg of CD4(+)CD25(high)CD45RA(+)CD62L(+) T cells during transplantation exhibited an increased incidence of II-IV aGVHD [hazard ratio (HR) = 0.000, 95% CI = 0.000-0.106, P = 0.013]. Next, we compared the reconstitution characteristics of T cell subsets between haploidentical haematopoietic stem cell transplantation (HSCT) and sibling HSCT by collecting peripheral blood samples at regular intervals (days 30, 60 and 90) after transplantation. No significant differences were observed in the reconstitution of conventional T cells between haploidentical HSCT and sibling identical HSCT. However, total counts of recovered naiveT(regs) and CD62L(+) naive T-regs from haploidentical HSCT were significantly lower compared to sibling identical HSCT; P-values were 0.045 and 0.021, respectively. Although total counts of conventional T cells in aGVHD patients reached similar levels compared to non-aGVHD patients before day 60 post-HSCT, total counts of naive T-regs and CD62L(+) naive T-regs in aGVHD patients did not reach similar levels to non-aGVHD patients until 90 days post-HSCT. Taken together, our findings demonstrate that a large population of CD62L(+) naive T-regs in allografts reduces the incidence of aGVHD. Further, development of aGVHD is related closely to the delayed reconstitution of the naive T-reg population.

语种: 英语
所属项目编号: 30725038 ; 30971292 ; 30800485 ; IRT0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; National Natural Science Foundation of China ; Program for Innovative Research Team in University
WOS记录号: WOS:000292338200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57568
Appears in Collections:北京大学第二临床医学院_北京大学血液病研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Inst Haematol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Haematol, Beijing 100044, Peoples R China

Recommended Citation:
Lu, S-Y.,Liu, K-Y.,Liu, D-H.,et al. High frequencies of CD62L(+) naive regulatory T cells in allografts are associated with a low risk of acute graft-versus-host disease following unmanipulated allogeneic haematopoietic stem cell transplantation[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY,2011,165(2):264-277.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lu, S-Y.]'s Articles
[Liu, K-Y.]'s Articles
[Liu, D-H.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lu, S-Y.]‘s Articles
[Liu, K-Y.]‘s Articles
[Liu, D-H.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace