学科主题临床医学
High frequencies of CD62L(+) naive regulatory T cells in allografts are associated with a low risk of acute graft-versus-host disease following unmanipulated allogeneic haematopoietic stem cell transplantation
Lu, S-Y.; Liu, K-Y.; Liu, D-H.; Xu, L-P.; Huang, X-J.1
关键词Acute Graft-versus-host Disease Allogeneic Haematopoietic Stem Cell Transplantation Immune Reconstitution Immune Tolerance Regulatory t Cell
刊名CLINICAL AND EXPERIMENTAL IMMUNOLOGY
2011-08-01
DOI10.1111/j.1365-2249.2011.04418.x
165期:2页:264-277
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]IDENTICAL SIBLING TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; IN-VITRO ; PERIPHERAL-BLOOD ; CUTTING EDGE ; CD4(+)CD25(+) ; GVHD ; TOLERANCE ; IMPACT ; VIVO
英文摘要

Regulatory T cells (T-regs) play a key role in the prevention of acute graft-versus-host disease (aGVHD). To investigate the association between T-reg subsets and aGVHD, we prospectively analysed T cell subsets in the allografts of 35 patients undergoing myeloablative unmanipulated haematopoietic stem cell transplantation. Multivariate analysis found that patients infused with less than 0.29 10(6)/kg of CD4(+)CD25(high)CD45RA(+)CD62L(+) T cells during transplantation exhibited an increased incidence of II-IV aGVHD [hazard ratio (HR) = 0.000, 95% CI = 0.000-0.106, P = 0.013]. Next, we compared the reconstitution characteristics of T cell subsets between haploidentical haematopoietic stem cell transplantation (HSCT) and sibling HSCT by collecting peripheral blood samples at regular intervals (days 30, 60 and 90) after transplantation. No significant differences were observed in the reconstitution of conventional T cells between haploidentical HSCT and sibling identical HSCT. However, total counts of recovered naiveT(regs) and CD62L(+) naive T-regs from haploidentical HSCT were significantly lower compared to sibling identical HSCT; P-values were 0.045 and 0.021, respectively. Although total counts of conventional T cells in aGVHD patients reached similar levels compared to non-aGVHD patients before day 60 post-HSCT, total counts of naive T-regs and CD62L(+) naive T-regs in aGVHD patients did not reach similar levels to non-aGVHD patients until 90 days post-HSCT. Taken together, our findings demonstrate that a large population of CD62L(+) naive T-regs in allografts reduces the incidence of aGVHD. Further, development of aGVHD is related closely to the delayed reconstitution of the naive T-reg population.

语种英语
WOS记录号WOS:000292338200014
项目编号30725038 ; 30971292 ; 30800485 ; IRT0702
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; National Natural Science Foundation of China ; Program for Innovative Research Team in University
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57568
专题北京大学第二临床医学院_北京大学血液病研究所
作者单位1.Peking Univ, Inst Haematol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Haematol, Beijing 100044, Peoples R China
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GB/T 7714
Lu, S-Y.,Liu, K-Y.,Liu, D-H.,et al. High frequencies of CD62L(+) naive regulatory T cells in allografts are associated with a low risk of acute graft-versus-host disease following unmanipulated allogeneic haematopoietic stem cell transplantation[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY,2011,165(2):264-277.
APA Lu, S-Y.,Liu, K-Y.,Liu, D-H.,Xu, L-P.,&Huang, X-J..(2011).High frequencies of CD62L(+) naive regulatory T cells in allografts are associated with a low risk of acute graft-versus-host disease following unmanipulated allogeneic haematopoietic stem cell transplantation.CLINICAL AND EXPERIMENTAL IMMUNOLOGY,165(2),264-277.
MLA Lu, S-Y.,et al."High frequencies of CD62L(+) naive regulatory T cells in allografts are associated with a low risk of acute graft-versus-host disease following unmanipulated allogeneic haematopoietic stem cell transplantation".CLINICAL AND EXPERIMENTAL IMMUNOLOGY 165.2(2011):264-277.
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