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学科主题: 临床医学
题名:
Nonesterified Fatty Acids and Cardiovascular Mortality in Elderly Men with CKD
作者: Xiong, Zibo1,2,4; Xu, Hong1,2; Huang, Xiaoyan4; Arnlov, Johan5,7; Qureshi, Abdul Rashid1,2; Cederholm, Tommy6; Sjogren, Per6; Lindholm, Bengt1,2; Riserus, Ulf6; Carrero, Juan Jesus1,2,3
刊名: CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
发表日期: 2015-04-01
DOI: 10.2215/CJN.08830914
卷: 10, 期:4, 页:584-591
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: SUDDEN CARDIAC DEATH ; GLOMERULAR-FILTRATION-RATE ; CHRONIC KIDNEY-DISEASE ; INSULIN SENSITIVITY ; DIALYSIS PATIENTS ; OXIDATIVE STRESS ; 70-YEAR-OLD MEN ; HEART-DISEASE ; RISK-FACTOR ; CARNITINE
英文摘要:

Background and objectives Although nonesterified fatty acids (NEFAs) are essential as energy substrate for the myocardium, an excess of circulating NEFAs can be harmful. This study aimed to assess plausible relationships between serum NEFA and mortality due to cardiovascular disease (CVD) in individuals with CKD.

Design, setting, participants, & measurements This was a prospective cohort study from the third examination cycle of the Uppsala LongitudinaL Study of Adult Men, a population-based survey of 1221 elderly men aged 70-71 years residing in Uppsala, Sweden. Data collection took place during 1991-1995. All participants had measures of kidney function; this study investigated 623 (51.7%) of these patients with manifest CKD (defined as either eGFR<60 ml/min per 1.73 m(2) or urine albumin excretion rate >= 20 mu g/min). Follow-up for mortality was done from examination date until death or December 31, 2007. After a median follow-up of 14 years (nterquartile range, 8-16.8), associations of NEFAs with mortality (related to all causes, CVD, ischemic heart disease [IHD], or acute myocardial infarction) were ascertained.

Results The median serum NEFA was 14.1 mg/dl (interquartile range, 11.3-17.8). No association was found with measures of kidney function. Diabetes and serum triglycerides were the only multivariate correlates of NEFA. During follow-up, 453 participants died, of which 209 deaths were due to CVD, including 88 IHD deaths, with 41 attributed to acute myocardial infarction (AMI). In fully adjusted covariates, serum NEFA was an independent risk factor for all-cause mortality (hazard ratio [HR] per log(2) increase, 1.22; 95% confidence interval [95% CI], 1.00 to 1.48) and CVD-related death (HR, 1.51; 95% CI, 1.15 to 1.99), including both IHD (HR, 1.51; 95% CI, 1.00 to 2.32) and AMI mortality (HR, 2.08; 95% CI, 1.09 to 3.98).

Conclusions Elevated serum NEFA associated with CVD mortality, and particularly with mortality due to AMI, in a homogeneous population of older men with moderate CKD.

语种: 英语
所属项目编号: K2012-99X-21949-01-3 ; 81402737
项目资助者: Swedish Research Council ; National Science Foundation for Young Scholars of China ; Karolinska Institute faculty (KID) ; Baxter Healthcare Corporation
WOS记录号: WOS:000352463400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57573
Appears in Collections:北京大学深圳医院_肾内科_期刊论文

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作者单位: 1.Karolinska Inst, Ctr Mol Med, SE-14186 Stockholm, Sweden
2.Uppsala Univ, Dept Med Sci, Mol Epidemiol, Uppsala, Sweden
3.Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden
4.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, SE-14186 Stockholm, Sweden
5.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, SE-14186 Stockholm, Sweden
6.Peking Univ, Shenzhen Hosp, Div Nephrol, Shenzhen, Guangdong, Peoples R China
7.Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr & Metab, Uppsala, Sweden

Recommended Citation:
Xiong, Zibo,Xu, Hong,Huang, Xiaoyan,et al. Nonesterified Fatty Acids and Cardiovascular Mortality in Elderly Men with CKD[J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2015,10(4):584-591.
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