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学科主题: 临床医学
题名:
S100A6 Overexpression Is Associated with Poor Prognosis and Is Epigenetically Up-Regulated in Gastric Cancer
作者: Wang, Xiao-Hong1; Zhang, Lian-Hai1; Zhong, Xi-Yao1; Xing, Xiao-Fang1; Liu, Yi-Qiang2; Niu, Zhao-Jian5; Peng, Yong1; Du, Hong3; Zhang, Gui-Guo3; Hu, Ying3; Liu, Ni1; Zhu, Yu-Bing1; Ge, Shao-Hua1; Zhao, Wei4; Lu, Ai-Ping2; Li, Ji-You2; Ji, Jia-Fu1
刊名: AMERICAN JOURNAL OF PATHOLOGY
发表日期: 2010-08-01
DOI: 10.2353/ajpath.2010.091217
卷: 177, 期:2, 页:586-597
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: GENE-EXPRESSION PATTERNS ; CALCIUM-BINDING PROTEIN ; CELL-LINES ; DIFFERENTIAL EXPRESSION ; TISSUE MICROARRAYS ; CALCYCLIN S100A6 ; TUMOR-SUPPRESSOR ; PROSTATE-CANCER ; BREAST-CANCER ; MARKER
英文摘要:

S100A6 has been implicated in a variety of biological functions as well as tumorigenesis. In this study, we investigated the expression status of S100A6 in relation to the clinicopathological features and prognosis of patients with gastric cancer and further explored a possible association of its expression with epigenetic regulation. S100A6 expression was remarkably increased in 67.5% of gastric cancer tissues as compared with matched noncancerous tissues. Statistical analysis demonstrated a clear correlation between high S100A6 expression and various clinicopathological features, such as depth of wall invasion, positive lymph node involvement, liver metastasis, vascular invasion, and tumor-node metastasis stage (P < 0.05 in all cases), as well as revealed that S100A6 is an independent prognostic predictor (P = 0.026) significantly related to poor prognosis (P = 0.0004). Further exploration found an inverse relationship between S100A6 expression and the methylation status of the seventh and eighth CpG sites in the promoter/first exon and the second to fifth sites in the second exon/second intron. In addition, the level of histone H3 acetylation was found to be significantly higher in S100A6-expressing cancer cells. After 5-azacytidine or trichostatin A treatment, S100A6 expression was clearly increased in S100A6 low-expressing cells. In conclusion, our results suggested that S100A6 plays an important role in the progression of gastric cancer, affecting patient prognosis, and is up-regulated by epigenetic regulation. (Am J Pathol 2010, 177:586-597; DOL. 10.2353/ajpath.2010.091217)

语种: 英语
所属项目编号: 30471677 ; D0905001040631
项目资助者: National Natural Science Foundation of China ; Foundation of Beijing Municipal Committee of Science Technology
WOS记录号: WOS:000280894600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57574
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Dept Surg,Minist Educ, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Dept Pathol,Minist Educ, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Tissue Bank,Minist Educ, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Beijing 100142, Peoples R China
4.Peking Univ, Sch Oncol, Clin Res Lab,Minist Educ, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Beijing 100142, Peoples R China
5.Shandong Univ, Dept Gen Surg, Qilu Hosp, Jinan 250100, Shandong, Peoples R China

Recommended Citation:
Wang, Xiao-Hong,Zhang, Lian-Hai,Zhong, Xi-Yao,et al. S100A6 Overexpression Is Associated with Poor Prognosis and Is Epigenetically Up-Regulated in Gastric Cancer[J]. AMERICAN JOURNAL OF PATHOLOGY,2010,177(2):586-597.
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