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S100A6 Overexpression Is Associated with Poor Prognosis and Is Epigenetically Up-Regulated in Gastric Cancer
Wang, Xiao-Hong1; Zhang, Lian-Hai1; Zhong, Xi-Yao1; Xing, Xiao-Fang1; Liu, Yi-Qiang2; Niu, Zhao-Jian5; Peng, Yong1; Du, Hong3; Zhang, Gui-Guo3; Hu, Ying3; Liu, Ni1; Zhu, Yu-Bing1; Ge, Shao-Hua1; Zhao, Wei4; Lu, Ai-Ping2; Li, Ji-You2; Ji, Jia-Fu1
刊名AMERICAN JOURNAL OF PATHOLOGY
2010-08-01
DOI10.2353/ajpath.2010.091217
177期:2页:586-597
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]GENE-EXPRESSION PATTERNS ; CALCIUM-BINDING PROTEIN ; CELL-LINES ; DIFFERENTIAL EXPRESSION ; TISSUE MICROARRAYS ; CALCYCLIN S100A6 ; TUMOR-SUPPRESSOR ; PROSTATE-CANCER ; BREAST-CANCER ; MARKER
英文摘要

S100A6 has been implicated in a variety of biological functions as well as tumorigenesis. In this study, we investigated the expression status of S100A6 in relation to the clinicopathological features and prognosis of patients with gastric cancer and further explored a possible association of its expression with epigenetic regulation. S100A6 expression was remarkably increased in 67.5% of gastric cancer tissues as compared with matched noncancerous tissues. Statistical analysis demonstrated a clear correlation between high S100A6 expression and various clinicopathological features, such as depth of wall invasion, positive lymph node involvement, liver metastasis, vascular invasion, and tumor-node metastasis stage (P < 0.05 in all cases), as well as revealed that S100A6 is an independent prognostic predictor (P = 0.026) significantly related to poor prognosis (P = 0.0004). Further exploration found an inverse relationship between S100A6 expression and the methylation status of the seventh and eighth CpG sites in the promoter/first exon and the second to fifth sites in the second exon/second intron. In addition, the level of histone H3 acetylation was found to be significantly higher in S100A6-expressing cancer cells. After 5-azacytidine or trichostatin A treatment, S100A6 expression was clearly increased in S100A6 low-expressing cells. In conclusion, our results suggested that S100A6 plays an important role in the progression of gastric cancer, affecting patient prognosis, and is up-regulated by epigenetic regulation. (Am J Pathol 2010, 177:586-597; DOL. 10.2353/ajpath.2010.091217)

语种英语
WOS记录号WOS:000280894600011
项目编号30471677 ; D0905001040631
资助机构National Natural Science Foundation of China ; Foundation of Beijing Municipal Committee of Science Technology
引用统计
被引频次:40[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57574
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_标本库
北京大学临床肿瘤学院_人力资源处
作者单位1.Peking Univ, Sch Oncol, Dept Surg,Minist Educ, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Dept Pathol,Minist Educ, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Tissue Bank,Minist Educ, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Beijing 100142, Peoples R China
4.Peking Univ, Sch Oncol, Clin Res Lab,Minist Educ, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Beijing 100142, Peoples R China
5.Shandong Univ, Dept Gen Surg, Qilu Hosp, Jinan 250100, Shandong, Peoples R China
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GB/T 7714
Wang, Xiao-Hong,Zhang, Lian-Hai,Zhong, Xi-Yao,et al. S100A6 Overexpression Is Associated with Poor Prognosis and Is Epigenetically Up-Regulated in Gastric Cancer[J]. AMERICAN JOURNAL OF PATHOLOGY,2010,177(2):586-597.
APA Wang, Xiao-Hong.,Zhang, Lian-Hai.,Zhong, Xi-Yao.,Xing, Xiao-Fang.,Liu, Yi-Qiang.,...&Ji, Jia-Fu.(2010).S100A6 Overexpression Is Associated with Poor Prognosis and Is Epigenetically Up-Regulated in Gastric Cancer.AMERICAN JOURNAL OF PATHOLOGY,177(2),586-597.
MLA Wang, Xiao-Hong,et al."S100A6 Overexpression Is Associated with Poor Prognosis and Is Epigenetically Up-Regulated in Gastric Cancer".AMERICAN JOURNAL OF PATHOLOGY 177.2(2010):586-597.
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