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Simple and safe production of yttrium-90 from a new type of Sr-90/Y-90 generator
Du, J; Chinol, M; Savonen, A; Hiltunen, J
关键词Yttrium-90 Generator System Acetate Buffer Targeted Radiotherapy
刊名RADIOCHIMICA ACTA
2005
93期:2页:111-113
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology
研究领域[WOS]Chemistry ; Nuclear Science & Technology
关键词[WOS]MONOCLONAL-ANTIBODY ; EXCHANGE ; THERAPY ; DTPA
英文摘要

Yttrium-90 (Y-90) has attracted much research attention in targeted radionuclide therapy because its many favorable properties and availability from a long shelf-life generator system. Although numerous generator systems have been developed for the production of Y-90, a common disadvantage is that the Y-90 is not eluted in an ionic form suitable for direct labeling of chelating agents bound to useful targeting molecules. In this study, we have adapted previously published procedures and developed a 740 MBq (20 mCi) of generator system in which the parent activity Sr-90 was retained on a cation exchange resin, while the daughter Y-90 activity was eluted with acetate buffer solution and used directly to label useful radioconjugates without further manipulations. A safety column, not loaded with Sr-90, was connected in series with the generator resulting in an eluate free of any Sr-90 breakthrough for at least eight months. The features of this new generator make it suitable for clinical applications.

语种英语
WOS记录号WOS:000227723300006
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57576
专题基础医学院
作者单位1.European Inst Oncol, Div Nucl Med, I-20141 Milan, Italy
2.MAP Med Technol Oy, Tikkakoski 41160, Finland
3.Peking Univ, Sch Basic Med Sci, Med Isotopes Res Ctr, Beijing 100083, Peoples R China
4.Univ Helsinki, Dept Chem, Lab Radiochem, FIN-00014 Helsinki, Finland
推荐引用方式
GB/T 7714
Du, J,Chinol, M,Savonen, A,et al. Simple and safe production of yttrium-90 from a new type of Sr-90/Y-90 generator[J]. RADIOCHIMICA ACTA,2005,93(2):111-113.
APA Du, J,Chinol, M,Savonen, A,&Hiltunen, J.(2005).Simple and safe production of yttrium-90 from a new type of Sr-90/Y-90 generator.RADIOCHIMICA ACTA,93(2),111-113.
MLA Du, J,et al."Simple and safe production of yttrium-90 from a new type of Sr-90/Y-90 generator".RADIOCHIMICA ACTA 93.2(2005):111-113.
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