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学科主题: 口腔医学
题名:
Morphology of bacterial flora in root canals associated with apical abscesses
作者: Guo Huijie1; Gao Chengzhi1; Zhang Chengfei3; Zheng Shuying2; Yue Lin4
关键词: apical abscess ; biofilm ; clinical symptoms ; dentinal tubules ; endodontic infection
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-09-20
DOI: 10.3760/cma.j.issn.0366-6999.20140965
卷: 127, 期:18, 页:3254-3258
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: DENTINAL TUBULES ; ENDODONTIC INFECTIONS ; PERIODONTITIS ; TEETH ; BIOFILMS
英文摘要:

Background Apical abscess is an inflammatory process in the peri-radicular tissues caused by biofilms in the necrotic root canal systems. Therefore, a comprehensive analysis of the bacterial colonization is required for a better understanding of the pathogenesis. This study aimed to investigate the patterns of bacterial infection of root canals of teeth with apical abscesses and to determine whether histological and microbiological findings correlated with clinical conditions.

Methods Eighteen samples from 18 teeth with apical pathological lesions were analyzed. Nine patients with acute apical abscesses experienced severe pain, and nine patients were asymptomatic with a sinus tract. After extraction, each affected root was divided into two halves. One half was processed for histobacteriologic analysis and examined using light microscopy, and the other half was analyzed using scanning electron microscopy (SEM) to determine the patterns of microbial colonization of the root canals.

Results The appearance of each sample subjected to SEM was consistent with the histobacteriologic findings despite the presence or absence of clinical symptoms. Intraradicular biofilms comprising cocci, rods, and/or filaments of amorphous materials were observed in the apical third of the main root canals in all samples. The bacterial biofilms covering the main root canal walls also penetrated the dentinal tubules to varying depths. The morphologies of biofilms varied, and a unique pattern of intraradicular infection was not identified.

Conclusion Intraradicular infections formed complex and variable multispecies biofilms and their presence did not correlate with clinical symptoms.

语种: 英语
所属项目编号: 8107088
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000343337300012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57578
Appears in Collections:北京大学第二临床医学院_口腔科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Stomatol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Electron Microscopy Lab, Beijing 100044, Peoples R China
3.Univ Hong Kong, Fac Dent, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Cariol Endodontol & Operat Dent, Beijing 100081, Peoples R China

Recommended Citation:
Guo Huijie,Gao Chengzhi,Zhang Chengfei,et al. Morphology of bacterial flora in root canals associated with apical abscesses[J]. CHINESE MEDICAL JOURNAL,2014,127(18):3254-3258.
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