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学科主题: 药学
题名:
Lanthanum chloride suppresses hydrogen peroxide-enhanced calcification in rat calcifying vascular cells
作者: Shi, Yu1; Gou, Bao-Di1; Shi, Yan-Ling2; Zhang, Tian-Lan1; Wang, Kui1
关键词: Lanthanum ; Hydrogen peroxide ; Calcifying vascular cells ; Calcification ; MAPK signaling
刊名: BIOMETALS
发表日期: 2009-04-01
DOI: 10.1007/s10534-008-9168-1
卷: 22, 期:2, 页:317-327
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: SMOOTH-MUSCLE-CELLS ; PROTEIN-KINASE-C ; OXIDATIVE STRESS ; ARTERIAL CALCIFICATION ; EXTRACELLULAR CALCIUM ; TYROSINE KINASE ; ACINAR-CELLS ; IN-VITRO ; MECHANISMS ; APOPTOSIS
英文摘要:

Lanthanum chloride (LaCl(3)) has been shown to retard the progression of established atherosclerotic lesions in animal models, and used as a calcium channel blocker in various cellular experiments. In this study, we assessed the role of lanthanum chloride (LaCl(3)) in H(2)O(2)-enhanced calcification in rat calcifying vascular cells (CVCs) and examined the involvement of MAPK signaling pathways. H(2)O(2) induced growth inhibition of CVCs, as well as increases in intracellular levels of calcium and reactive oxygen species, ALP activity, apoptosis and calcium deposition. These effects of H(2)O(2) were suppressed by pretreatment of the cells with 1 mu M of LaCl(3) for 2 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2, JNK and p38 MAPK, but only the last two were associated with the ALP activity. Our findings demonstrate that H(2)O(2)-enhanced osteoblastic differentiation and apoptosis are responsible for the increased calcification in rat CVCs, and LaCl(3) can counteract these effects by suppressing the activation of JNK (JNK2, but not JNK1) and p38 MAPK signaling pathway.

语种: 英语
所属项目编号: 20571006 ; 20637010 ; 2007CB516806
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China ; Beijing Talent Project
WOS记录号: WOS:000264546600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57581
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Capital Med Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100069, Peoples R China

Recommended Citation:
Shi, Yu,Gou, Bao-Di,Shi, Yan-Ling,et al. Lanthanum chloride suppresses hydrogen peroxide-enhanced calcification in rat calcifying vascular cells[J]. BIOMETALS,2009,22(2):317-327.
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