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学科主题: 临床医学
题名:
Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: A meta-analysis of randomized controlled trials
作者: Zhao, Yun-Tao1; Chen, Qiang2; Sun, Ya-Xun1; Li, Xue-Bin1; Zhang, Ping1; Xu, Yuan1; Guo, Ji-Hong1
关键词: Meta-analysis ; omega-3 fatty acids ; randomized controlled trials ; sudden cardiac death
刊名: ANNALS OF MEDICINE
发表日期: 2009
DOI: 10.1080/07853890802698834
卷: 41, 期:4, 页:301-310
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: POLYUNSATURATED FATTY-ACIDS ; ACUTE MYOCARDIAL-INFARCTION ; RAT VENTRICULAR MYOCYTES ; ALPHA-LINOLENIC ACID ; FISH-OIL ; SECONDARY-PREVENTION ; CARDIOVASCULAR-DISEASE ; EICOSAPENTAENOIC ACID ; RISK ; DIET
英文摘要:

Aim. To systematically review trials concerning the effects of omega-3 fatty acids on sudden cardiac death (SCD), cardiac death, and all-cause mortality in coronary heart disease (CHD) patients. Methods. PubMed, Embase, and the Cochrane database (1966-2007) were searched. We identified randomized controlled trials that compared dietary or supplementary intake of omega-3 fatty acids with control diet or placebo in CHD patients. Eligible studies had at least 6 months of follow-up data, and cited SCD as an end-point. Two reviewers independently assessed methodological quality. Meta-analysis of relative risk was carried out using the random effect model. Results. Eight trials were identified, comprising 20,997 patients. In patients with prior myocardial infarction (MI), omega-3 fatty acids reduced relative risk (RR) of SCD (RR = 0.43; 95% CI: 0.20-0.91). In patients with angina, omega-3 fatty acids increased RR of SCD (RR = 1.39; 95% CI: 1.01-1.92). Overall, RR for cardiac death and all-cause mortality were 0.71 (95% CI: 0.50-1.00) and 0.77 (95% CI: 0.58-1.01), respectively. Conclusions. Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with MI, but may have adverse effects in angina patients.

语种: 英语
所属项目编号: 2007CB512008
项目资助者: Major State Basic Research Development Program of China (973 Program)
WOS记录号: WOS:000265290400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57582
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
2.Chinese Ctr Dis Control & Prevent, Ctr Publ Hlth Surveillance & Informat Serv, Beijing, Peoples R China

Recommended Citation:
Zhao, Yun-Tao,Chen, Qiang,Sun, Ya-Xun,et al. Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: A meta-analysis of randomized controlled trials[J]. ANNALS OF MEDICINE,2009,41(4):301-310.
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