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学科主题: 临床医学
题名:
Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China
作者: Lu, Zhongqiang; Cao, Yanyan; Wang, Yimin; Zhang, Qingjun; Zhang, Xianghong; Wang, Shuheng; Li, Yuehong; Xie, Huiling; Jiao, Baohua; Zhang, Jianhui
关键词: matrix metalloproteinase ; single nucleotide polymorphism ; glioma ; astrocytoma ; susceptibility
刊名: JOURNAL OF NEURO-ONCOLOGY
发表日期: 2007-10-01
DOI: 10.1007/s11060-007-9392-5
卷: 85, 期:1, 页:65-73
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Clinical Neurology
研究领域[WOS]: Oncology ; Neurosciences & Neurology
关键词[WOS]: SINGLE NUCLEOTIDE POLYMORPHISM ; CELL LUNG-CARCINOMA ; CORONARY ATHEROSCLEROSIS ; GENETIC-VARIATION ; FUNCTIONAL POLYMORPHISM ; CANCER SUSCEPTIBILITY ; OVARIAN-CANCER ; ASSOCIATION ; PROGRESSION ; RISK
英文摘要:

The single nucleotide polymorphisms (SNPs) in the promoter region of matrix metalloproteinase (MMP) genes may influence tumor occurrence and progression via modifying mRNA transcription and protein expression. The study aims to explore the association of the SNPs in MMP-1, 3 and MMP-9 promoters with susceptibility to adult brain astrocytoma in northern China. Genotyping for the MMP-1 -1607 2G/1G, MMP-3 -1171 5A/6A, and MMP-9 -1562 C/T SNPs were performed by PCR-RFLP methods among 236 adult astrocytoma patients and 366 healthy controls. The results showed that the overall distribution of the MMP-1 allelotype and genotype among astrocytoma patients and healthy controls was significantly different (P = 0.002 and P < 0.001, respectively). Compared with the 2G/2G genotype, the 1G/1G genotype significantly decreased the risk of astrocytoma development (adjusted OR = 0.58, 95% CI = 0.42-0.79). The similar results were obtained when stratified by gender and age at tumor diagnosis (<= 45 or >45 years). The association between MMP-3 -1171 5A/6A or MMP-9 -1562 C/T SNPs and susceptibility to astrocytoma was not observed in this study. However, MMP-1 1G-MMP-3 6A haplotype significantly reduced the risk of astrocytoma development when using MMP-1 2G-MMP-3 6A haplotype as a reference (OR = 0.45, 95% CI = 0.29-0.67). The present study suggested that, the MMP-1 -1607 1G/1G genotype and MMP-1 1G-MMP-3 6A haplotype may play protective role in the development of adult astrocytoma in northern Chinese, whereas the MMP-3 -1171 5A/6A and MMP-9 -1562 C/T polymorphisms may not be independent factors to influence susceptibility to adult astrocytoma in this population.

语种: 英语
WOS记录号: WOS:000249458000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57583
Appears in Collections:北京大学第二临床医学院_神经外科_期刊论文

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作者单位: 1.Hebei Med Univ, Hosp 2, Dept Neurosurg, Shijiazhuang 050000, Hebei Province, Peoples R China
2.Hebei Med Univ, Hebei Canc Inst, Shijiazhuang 050011, Hebei Province, Peoples R China
3.Beijing Univ, Renmin Hosp, Dept Neurosurg, Beijing 100044, Peoples R China
4.Hebei Med Univ, Hosp 2, Dept Pathol, Shijiazhuang 050000, Hebei Province, Peoples R China

Recommended Citation:
Lu, Zhongqiang,Cao, Yanyan,Wang, Yimin,et al. Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China[J]. JOURNAL OF NEURO-ONCOLOGY,2007,85(1):65-73.
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