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Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells
Gu, Huiping2; Cui, Ming2; Bai, Yun3; Chen, Fengrong2; Ma, Kangtao1; Zhou, Chunyan1; Guo, Lijun2
关键词Angiopoietin-1 Tie2 Receptor Macrophage Cells Inflammatory Nf-kappa b
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2010-02-05
DOI10.1016/j.bbrc.2010.01.009
392期:2页:178-182
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]NF-KAPPA-B ; TYROSINE KINASE ; RECEPTOR ; ATHEROSCLEROSIS ; ANGIOGENESIS ; EXPRESSION ; MIGRATION ; PROTEIN ; ABIN-2 ; GAMMA
英文摘要

Angiopoietin-1 (Ang1) is a ligand for the endothelial-specific tyrosine kinase receptor Tie2 and has been shown to play an essential role in embryonic vasculature development. There have been many studies about the anti-inflammatory effects of Ang1, most of which focus on endothelium cells. in the present Study, we explore the role of Ang1-Tie2 signaling in the activation of macrophages upon lipopolysaccharide (LPS) stimulation. We found that Tie2 receptor is expressed on macrophages and Ang1 could inhibit LPS-induced activation of macrophages, as evidenced by cell migration and TNF-alpha production, specifically through Tie2 receptor. We further investigated the mechanism and found that Ang1-Tie2 could block LPS-induced activation of NF-kappa B which has been shown to be necessary for macrophage activation with LPS treatment. Thus, we described, for the first time, the role of Ang1-Tie2 signaling in macrophage activation and the possible mechanisms in response to immune stimulation. (C) 2010 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000274743000013
项目编号7102099 ; 30600167 ; 09010040159
资助机构Beijing Natural Science Foundation ; National Natural Sciences Foundation of China ; Chinese Medical Association
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57584
专题北京大学基础医学院
北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Gu, Huiping,Cui, Ming,Bai, Yun,et al. Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,392(2):178-182.
APA Gu, Huiping.,Cui, Ming.,Bai, Yun.,Chen, Fengrong.,Ma, Kangtao.,...&Guo, Lijun.(2010).Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,392(2),178-182.
MLA Gu, Huiping,et al."Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 392.2(2010):178-182.
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