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学科主题: 基础医学
题名:
Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells
作者: Gu, Huiping2; Cui, Ming2; Bai, Yun3; Chen, Fengrong2; Ma, Kangtao1; Zhou, Chunyan1; Guo, Lijun2
关键词: Angiopoietin-1 ; Tie2 receptor ; Macrophage cells ; Inflammatory ; NF-kappa B
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2010-02-05
DOI: 10.1016/j.bbrc.2010.01.009
卷: 392, 期:2, 页:178-182
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: NF-KAPPA-B ; TYROSINE KINASE ; RECEPTOR ; ATHEROSCLEROSIS ; ANGIOGENESIS ; EXPRESSION ; MIGRATION ; PROTEIN ; ABIN-2 ; GAMMA
英文摘要:

Angiopoietin-1 (Ang1) is a ligand for the endothelial-specific tyrosine kinase receptor Tie2 and has been shown to play an essential role in embryonic vasculature development. There have been many studies about the anti-inflammatory effects of Ang1, most of which focus on endothelium cells. in the present Study, we explore the role of Ang1-Tie2 signaling in the activation of macrophages upon lipopolysaccharide (LPS) stimulation. We found that Tie2 receptor is expressed on macrophages and Ang1 could inhibit LPS-induced activation of macrophages, as evidenced by cell migration and TNF-alpha production, specifically through Tie2 receptor. We further investigated the mechanism and found that Ang1-Tie2 could block LPS-induced activation of NF-kappa B which has been shown to be necessary for macrophage activation with LPS treatment. Thus, we described, for the first time, the role of Ang1-Tie2 signaling in macrophage activation and the possible mechanisms in response to immune stimulation. (C) 2010 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 7102099 ; 30600167 ; 09010040159
项目资助者: Beijing Natural Science Foundation ; National Natural Sciences Foundation of China ; Chinese Medical Association
WOS记录号: WOS:000274743000013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57584
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Gu, Huiping,Cui, Ming,Bai, Yun,et al. Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,392(2):178-182.
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