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学科主题临床医学
Effect of sulfur dioxide preconditioning on rat myocardial ischemia/reperfusion injury by inducing endoplasmic reticulum stress
Wang, Xin-Bao1; Huang, Xiao-Mei1; Ochs, Todd2; Li, Xue-Ying3; Jin, Hong-Fang1; Tang, Chao-Shu4,5; Du, Jun-Bao1
关键词Sulfur Dioxide Preconditioning Ischemia Reperfusion Endoplasmic Reticulum Stress
刊名BASIC RESEARCH IN CARDIOLOGY
2011-09-01
DOI10.1007/s00395-011-0176-x
106期:5页:865-878
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者National Natural Science Foundation of China ; Changjiang Scholar Program ; Ministry of Education, China ; Major Basic Research Program of China ; National Natural Science Foundation of China ; Changjiang Scholar Program ; Ministry of Education, China ; Major Basic Research Program of China
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ISCHEMIA-REPERFUSION INJURY ; SERUM SULFITE ; EARLY REVASCULARIZATION ; TRANSITION PORE ; NITRIC-OXIDE ; CELL-DEATH ; PROTECTS ; DERIVATIVES ; INHIBITION ; EXPRESSION
英文摘要

Sulfur dioxide has recently been found to be produced endogenously in the cardiovascular system and have important positive biological effects. However, it is unknown whether sulfur dioxide preconditioning has a protective effect on rat myocardial ischemia/reperfusion (I/R) injury and whether this process involves endoplasmic reticulum stress (ERS). In this study, we showed that preconditioning with sulfur dioxide 10 min before ischemia (with a low concentration of sulfur dioxide of 1-10 mu mol/kg) could reduce myocardial infarct size and plasma activities of lactate dehydrogenase and creatine kinase in rats with I/R in vivo. Sulfur dioxide preconditioning also reduced myocardium apoptosis induced by I/R. In addition, sulfur dioxide preconditioning increased cardiac function in vitro. Sulfur dioxide preconditioning induced expression of myocardial glucose-regulated protein 78 (GRP78) and phosphorylated eukaryotic initiation of the factor 2 alpha-subunit (p-eIF2 alpha) prior to myocardial I/R but suppressed expression of myocardial GRP78, C/EBP homologous protein, and p-eIF2 alpha during myocardial I/R, in association with improved myocardial injury in vivo and in vitro. Pretreatment with dithiothreitol, an ERS stimulator mimicked the above cardioprotective effect. However, pretreatment with the ERS inhibitor 4-phenylbutyrate reversed the cardioprotection provided by sulfur dioxide preconditioning. These data indicated that sulfur dioxide preconditioning reduced I/R-induced myocardial injury in vivo and in vitro, and that augmenting ERS by sulfur dioxide preconditioning prior to I/R contributed to protection against myocardial I/R injury.

语种英语
所属项目编号30821001 ; 81070111 ; 81070212 ; 20070001770 ; 307001 ; 20070001702 ; 2011CB503904
资助者National Natural Science Foundation of China ; Changjiang Scholar Program ; Ministry of Education, China ; Major Basic Research Program of China ; National Natural Science Foundation of China ; Changjiang Scholar Program ; Ministry of Education, China ; Major Basic Research Program of China
WOS记录号WOS:000293533000013
Citation statistics
Cited Times:49[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57587
Collection北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Dept Stat, Hosp 1, Beijing 100034, Peoples R China
2.Minist Educ, Key Lab Mol Cardiol, Beijing 100191, Peoples R China
3.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
4.Univ Illinois, Sch Med, Chicago, IL USA
5.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xin-Bao,Huang, Xiao-Mei,Ochs, Todd,et al. Effect of sulfur dioxide preconditioning on rat myocardial ischemia/reperfusion injury by inducing endoplasmic reticulum stress[J]. BASIC RESEARCH IN CARDIOLOGY,2011,106(5):865-878.
APA Wang, Xin-Bao.,Huang, Xiao-Mei.,Ochs, Todd.,Li, Xue-Ying.,Jin, Hong-Fang.,...&Du, Jun-Bao.(2011).Effect of sulfur dioxide preconditioning on rat myocardial ischemia/reperfusion injury by inducing endoplasmic reticulum stress.BASIC RESEARCH IN CARDIOLOGY,106(5),865-878.
MLA Wang, Xin-Bao,et al."Effect of sulfur dioxide preconditioning on rat myocardial ischemia/reperfusion injury by inducing endoplasmic reticulum stress".BASIC RESEARCH IN CARDIOLOGY 106.5(2011):865-878.
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