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学科主题基础医学
Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain
Zhang, Ying; Li, Yi; Yang, Yan-Rui; Zhu, Hai-Hao; Han, Ji-Sheng; Wang, Yun
关键词Complete Freund&Prime s Adjuvant Immunofluorescence Nociception Spinal Dorsal Horn Transcription Factor
刊名NEUROCHEMICAL RESEARCH
2007-09-01
DOI10.1007/s11064-007-9364-3
32期:9页:1592-1599
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]TRANSCRIPTIONAL REPRESSOR DREAM ; GENE-EXPRESSION ; POTASSIUM CHANNELS ; BINDING PROTEIN ; ALPHA-SUBUNITS ; DORSAL-HORN ; KV4.2 ; CALSENILIN ; NEURONS ; INTERNEURONS
英文摘要

A previous knockout study revealed the critical role of downstream regulatory element antagonist modulator (DREAM) in pain processing in the spinal cord by transcriptional regulation of prodynorphin (PPD) gene. Here, we report that, in contrast to the nuclear localization of other transcription factors, DREAM showed a punctate staining pattern in rat spinal dorsal horn in immunofluorescent analysis, with a membrane localization profile in some neurons and its expression accumulated in the inner zone of lamina II. In an inflammatory pain model induced by complete Freund′s adjuvant (CFA) injection, we used Western blot analysis and detected transient upregulation of DREAM in the nuclear fraction of ipsilateral spinal dorsal horn at 2 h and 6 h post-injection, and a slow upregulation in the membrane fraction for 7 days. These studies suggest that DREAM might have other roles in pain modulation in the spinal cord in addition to its well-known role as a transcriptional repressor.

语种英语
WOS记录号WOS:000248190200020
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57589
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Dept Neurobiol, Beijing 100083, Peoples R China
2.Peking Univ, Neurosci Res Inst, Dept Neurobiol, Key Lab Neurosci,Minist Educ,Hlth Sci Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Zhang, Ying,Li, Yi,Yang, Yan-Rui,et al. Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain[J]. NEUROCHEMICAL RESEARCH,2007,32(9):1592-1599.
APA Zhang, Ying,Li, Yi,Yang, Yan-Rui,Zhu, Hai-Hao,Han, Ji-Sheng,&Wang, Yun.(2007).Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain.NEUROCHEMICAL RESEARCH,32(9),1592-1599.
MLA Zhang, Ying,et al."Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain".NEUROCHEMICAL RESEARCH 32.9(2007):1592-1599.
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