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学科主题: 基础医学
题名:
Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain
作者: Zhang, Ying; Li, Yi; Yang, Yan-Rui; Zhu, Hai-Hao; Han, Ji-Sheng; Wang, Yun
关键词: complete Freund&prime ; s adjuvant ; immunofluorescence ; nociception ; spinal dorsal horn ; transcription factor
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2007-09-01
DOI: 10.1007/s11064-007-9364-3
卷: 32, 期:9, 页:1592-1599
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: TRANSCRIPTIONAL REPRESSOR DREAM ; GENE-EXPRESSION ; POTASSIUM CHANNELS ; BINDING PROTEIN ; ALPHA-SUBUNITS ; DORSAL-HORN ; KV4.2 ; CALSENILIN ; NEURONS ; INTERNEURONS
英文摘要:

A previous knockout study revealed the critical role of downstream regulatory element antagonist modulator (DREAM) in pain processing in the spinal cord by transcriptional regulation of prodynorphin (PPD) gene. Here, we report that, in contrast to the nuclear localization of other transcription factors, DREAM showed a punctate staining pattern in rat spinal dorsal horn in immunofluorescent analysis, with a membrane localization profile in some neurons and its expression accumulated in the inner zone of lamina II. In an inflammatory pain model induced by complete Freund′s adjuvant (CFA) injection, we used Western blot analysis and detected transient upregulation of DREAM in the nuclear fraction of ipsilateral spinal dorsal horn at 2 h and 6 h post-injection, and a slow upregulation in the membrane fraction for 7 days. These studies suggest that DREAM might have other roles in pain modulation in the spinal cord in addition to its well-known role as a transcriptional repressor.

语种: 英语
WOS记录号: WOS:000248190200020
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57589
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Dept Neurobiol, Beijing 100083, Peoples R China
2.Peking Univ, Neurosci Res Inst, Dept Neurobiol, Key Lab Neurosci,Minist Educ,Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Ying,Li, Yi,Yang, Yan-Rui,et al. Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain[J]. NEUROCHEMICAL RESEARCH,2007,32(9):1592-1599.
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