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学科主题: 临床医学
题名:
Cultured lung fibroblasts from ovalbumin-challenged "Asthmatic" mice differ functionally from normal
作者: Sugiura, Hisatoshi; Liu, Xiangde; Duan, Fenghai; Kawasaki, Shin; Togo, Shinsaku; Kamio, Koichiro; Wang, Xing Qi; Mao, Lijun; Ahn, Youngsoo; Ertl, Ronald F.; Bargar, Tom W.; Berro, Abdo; Casale, Thomas B.; Rennard, Stephen I.
关键词: remodeling ; fibroblast ; phenotype ; mouse model
刊名: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
发表日期: 2007-10-01
DOI: 10.1165/rcmb.2007-0089OC
卷: 37, 期:4, 页:424-430
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Respiratory System
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Respiratory System
关键词[WOS]: LATE ALLERGIC RESPONSE ; AIRWAY HYPERRESPONSIVENESS ; CELL-PROLIFERATION ; SUBEPITHELIAL FIBROSIS ; MYCOBACTERIAL ANTIGENS ; MOUSE MODEL ; INFLAMMATION ; MYOFIBROBLASTS ; MATRIX ; INJURY
英文摘要:

Asthmatic airway remodeling is characterized by goblet cell hyperplasia, angiogenesis, smooth muscle hypertrophy, and subepithelial fibrosis. This study evaluated whether acquired changes in fibroblast phenotype could contribute to this remodeling. Airway and parenchymal fibroblasts from control or chronically ovalbumin (OVA)sensitized and challenged "asthmatic" mice were assessed for several functions related to repair and remodeling +/- exogenous transforming growth factor (TGF)-beta. All OVA-challenged mouse fibroblasts demonstrated augmented gel contraction (P < 0.05) and chemotaxis (P < 0.05); increased TGF-beta(1) (P < 0.05), fibronectin (P < 0.05), and vascular enclothelial growth factor (P < 0.05) release; and expressed more a-smooth muscle actin (P < 0.05). TGF-beta(1) stimulated both control and asthmatic fibroblasts, which retained all differences from control fibroblasts for all features(P < 0.05, all comparisons). Parenchymal fibroblasts proliferated more rapidly (P < 0.05), while airway fibroblasts proliferated similarly compared with control fibroblasts (P = 0.25). Thus, in this animal model, OVA-challenged mouse fibroblasts acquire a distinct phenotype that differs from control fibroblasts. The augmented profibrotic activity and mediator release of asthmatic fibroblasts could contribute to airway remodeling in asthma.

语种: 英语
WOS记录号: WOS:000249898400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57590
Appears in Collections:北京大学第三临床医学院_风湿免疫科_期刊论文

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作者单位: 1.Univ Nebraska Med Ctr, Omaha, NE USA
2.Wakayama Med Univ, Dept Internal Med 3, Wakayama, Japan
3.Univ Nebraska, Med Ctr, Omaha, NE 68198 USA
4.Univ Nebraska Med Ctr, Pulm & Crit Care Med, Omaha, NE USA
5.Univ Nebraska Med Ctr, Prevent & Soc Med, Omaha, NE USA
6.Peking Univ, Third Hosp, Dept Rheumatol, Beijing, Peoples R China
7.Creighton Univ, Med Ctr, Div Allergy & Immunol, Omaha, NE 68178 USA

Recommended Citation:
Sugiura, Hisatoshi,Liu, Xiangde,Duan, Fenghai,et al. Cultured lung fibroblasts from ovalbumin-challenged "Asthmatic" mice differ functionally from normal[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY,2007,37(4):424-430.
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