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学科主题临床医学
Cultured lung fibroblasts from ovalbumin-challenged "Asthmatic" mice differ functionally from normal
Sugiura, Hisatoshi; Liu, Xiangde; Duan, Fenghai; Kawasaki, Shin; Togo, Shinsaku; Kamio, Koichiro; Wang, Xing Qi; Mao, Lijun; Ahn, Youngsoo; Ertl, Ronald F.; Bargar, Tom W.; Berro, Abdo; Casale, Thomas B.; Rennard, Stephen I.
关键词Remodeling Fibroblast Phenotype Mouse Model
刊名AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
2007-10-01
DOI10.1165/rcmb.2007-0089OC
37期:4页:424-430
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Respiratory System
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Respiratory System
关键词[WOS]LATE ALLERGIC RESPONSE ; AIRWAY HYPERRESPONSIVENESS ; CELL-PROLIFERATION ; SUBEPITHELIAL FIBROSIS ; MYCOBACTERIAL ANTIGENS ; MOUSE MODEL ; INFLAMMATION ; MYOFIBROBLASTS ; MATRIX ; INJURY
英文摘要

Asthmatic airway remodeling is characterized by goblet cell hyperplasia, angiogenesis, smooth muscle hypertrophy, and subepithelial fibrosis. This study evaluated whether acquired changes in fibroblast phenotype could contribute to this remodeling. Airway and parenchymal fibroblasts from control or chronically ovalbumin (OVA)sensitized and challenged "asthmatic" mice were assessed for several functions related to repair and remodeling +/- exogenous transforming growth factor (TGF)-beta. All OVA-challenged mouse fibroblasts demonstrated augmented gel contraction (P < 0.05) and chemotaxis (P < 0.05); increased TGF-beta(1) (P < 0.05), fibronectin (P < 0.05), and vascular enclothelial growth factor (P < 0.05) release; and expressed more a-smooth muscle actin (P < 0.05). TGF-beta(1) stimulated both control and asthmatic fibroblasts, which retained all differences from control fibroblasts for all features(P < 0.05, all comparisons). Parenchymal fibroblasts proliferated more rapidly (P < 0.05), while airway fibroblasts proliferated similarly compared with control fibroblasts (P = 0.25). Thus, in this animal model, OVA-challenged mouse fibroblasts acquire a distinct phenotype that differs from control fibroblasts. The augmented profibrotic activity and mediator release of asthmatic fibroblasts could contribute to airway remodeling in asthma.

语种英语
WOS记录号WOS:000249898400008
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57590
专题北京大学第三临床医学院_风湿免疫科
作者单位1.Univ Nebraska Med Ctr, Omaha, NE USA
2.Wakayama Med Univ, Dept Internal Med 3, Wakayama, Japan
3.Univ Nebraska, Med Ctr, Omaha, NE 68198 USA
4.Univ Nebraska Med Ctr, Pulm & Crit Care Med, Omaha, NE USA
5.Univ Nebraska Med Ctr, Prevent & Soc Med, Omaha, NE USA
6.Peking Univ, Third Hosp, Dept Rheumatol, Beijing, Peoples R China
7.Creighton Univ, Med Ctr, Div Allergy & Immunol, Omaha, NE 68178 USA
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Sugiura, Hisatoshi,Liu, Xiangde,Duan, Fenghai,et al. Cultured lung fibroblasts from ovalbumin-challenged "Asthmatic" mice differ functionally from normal[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY,2007,37(4):424-430.
APA Sugiura, Hisatoshi.,Liu, Xiangde.,Duan, Fenghai.,Kawasaki, Shin.,Togo, Shinsaku.,...&Rennard, Stephen I..(2007).Cultured lung fibroblasts from ovalbumin-challenged "Asthmatic" mice differ functionally from normal.AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY,37(4),424-430.
MLA Sugiura, Hisatoshi,et al."Cultured lung fibroblasts from ovalbumin-challenged "Asthmatic" mice differ functionally from normal".AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 37.4(2007):424-430.
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