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Attenuating effect of post-treatment with QiShenYiQi Pills on myocardial fibrosis in rat cardiac hypertrophy
Li, Yan-Chuan2,3; Liu, Yu-Ying2; Hu, Bai-He2; Chang, Xin2; Fan, Jing-Yu2; Sun, Kai2; Wei, Xiao-Hong2; Pan, Chun-Shui2; Huang, Ping2; Chen, Yuan-Yuan2; Wang, Chuan-She2; Zheng, Jun2; Han, Jing-Yan1,2
关键词Pressure Overload Cardiac Fibrosis Salvia Miltiorrhiza Transforming Growth Factor Beta 1
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2012
DOI10.3233/CH-2011-1523
51期:3页:177-191
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]INDUCED MICROCIRCULATORY DISTURBANCE ; SALVIANOLIC-ACID-B ; GENE-EXPRESSION ; ANGIOTENSIN-II ; DYSFUNCTION ; HEART ; MODULATION ; PROTECTION ; MESENTERY ; INJURY
英文摘要

QiShenYiQi Pills (R) (QSYQ) is a compound Chinese medicine used for treatment of cardiovascular diseases. However, the potential of QSYQ to inhibit cardiac fibrosis in left ventricle hypertrophy is not explored to date. We investigated the effects of post-treatment with QSYQ on rat myocardial fibrosis in left ventricle hypertrophy induced by pressure over-load through ascending aortic stenosis. QSYQ was administrated 4 weeks after the surgery, at a dose of 0.8 g/kg/day over the next 4 weeks, while echocardiography was performed 4 and 8 weeks, respectively, after the surgery. Eight weeks after the surgery, myocardial blood flow was determined by Laser-Doppler Perfusion Imager and the ratio of heart weight to body weight (HW/BW) was estimated, in concurrent evaluation of myocardial histology and ultrastructure, as well as collagen content by sirius red staining, and immunohistochemistry staining for CD68 and transforming growth factor beta 1. Post-treatment with QSYQ significantly alleviated left ventricular posterior wall end diastolic thickness and the HW/BW, increased left ventricle ejection fraction and left ventricle fractional shortening. QSYQ also decreased myocardial fibrosis size. The expression of CD68 and transforming growth factor beta 1 were obviously suppressed after QSYQ treatment. The results suggest that post-treatment with QSYQ attenuates pressure over-load-induced cardiac hypertrophy and myocardial fibrosis through interfering in inflammatory process.

语种英语
WOS记录号WOS:000306291700003
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57596
专题北京大学基础医学院
北京大学医学部管理机构_医学部
北京大学第二临床医学院_心血管内科
北京大学第三临床医学院_骨科
作者单位1.Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Yan-Chuan,Liu, Yu-Ying,Hu, Bai-He,et al. Attenuating effect of post-treatment with QiShenYiQi Pills on myocardial fibrosis in rat cardiac hypertrophy[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2012,51(3):177-191.
APA Li, Yan-Chuan.,Liu, Yu-Ying.,Hu, Bai-He.,Chang, Xin.,Fan, Jing-Yu.,...&Han, Jing-Yan.(2012).Attenuating effect of post-treatment with QiShenYiQi Pills on myocardial fibrosis in rat cardiac hypertrophy.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,51(3),177-191.
MLA Li, Yan-Chuan,et al."Attenuating effect of post-treatment with QiShenYiQi Pills on myocardial fibrosis in rat cardiac hypertrophy".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 51.3(2012):177-191.
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