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学科主题: 口腔医学
题名:
A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region
作者: Yu, G. -Y.1,2; Gao, Y.3,4; Peng, X.1,2; Chen, Y.3,4; Zhao, F. -Y.1,2; Wu, M-J1,2
关键词: basaloid squamous cell carcinoma ; squamous cell carcinoma ; oral mucosa ; head and neck ; diagnosis prognosis ; pathology ; immunohistochemistry
刊名: INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
发表日期: 2008-11-01
DOI: 10.1016/j.ijom.2008.05.019
卷: 37, 期:11, 页:1003-1008
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]: ADENOID CYSTIC CARCINOMA ; DIFFERENTIAL-DIAGNOSIS ; LARYNX ; HYPOPHARYNX ; NECK ; HEAD ; NEOPLASM ; FEATURES ; CAVITY ; TRACT
英文摘要:

Basaloid squamous Cell carcinoma (BSCC) is a rare distinct variant of squamous Cell carcinoma (SCC). To investigate its clinical behavior and prognosis, 15 patients with BSCC in the oral and maxillofacial region were clinically analyzed and compared with 15 patients with conventional SCC matched for site, stage, gender and age. TO understand its immunohistochemical features, sections for cytokeratin AE1/AE3, CK 13. CK 7, CK 8, proliferating cell nuclear antigen (PCNA) and p53 were reviewed from 12 patients with BSCC. The rate of cervical lymph node metastasis of BSCC was as high as 67% and that of distant metastasis 13%. The tumor recurrence rate was 33% and the 3-year and 5-year Survival rates were 53% and 32%, respectively. For conventional SCC, the cervical lymph node metastasis rate was 27%, that of distant metastasis 7%, tumor recurrence rate was 33%, and 3-year and 5-year survival rates were 80% and 70%, respectively. In most BSCC patients(10/12)the PCNA index was over 50%. Twelve BSCC patients were diagnosed with grade II or III conventional SCC when the original records of the primary diagnosis for the 15 patients with BSCC were reviewed. The biological behavior and prognosis of BSCC are similar to those of poorly differentiated SCC.

语种: 英语
WOS记录号: WOS:000261328000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57601
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Oral & Maxillofacial Surg, Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Dept Oral Pathol, Sch Stomatol, Beijing 100081, Peoples R China
4.Peking Univ, Dept Oral Pathol, Hosp Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Yu, G. -Y.,Gao, Y.,Peng, X.,et al. A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region[J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2008,37(11):1003-1008.
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