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学科主题: 基础医学
题名:
Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA
作者: Bi, Junfeng1,2; Wang, Wei1; Liu, Zhonghua1; Huang, Xiahe1; Jiang, Qingqing1,3,4; Liu, George3,4; Wang, Yingchun; Huang, Xun1
刊名: CELL METABOLISM
发表日期: 2014-05-06
DOI: 10.1016/j.cmet.2014.03.028
卷: 19, 期:5, 页:861-871
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Endocrinology & Metabolism
研究领域[WOS]: Cell Biology ; Endocrinology & Metabolism
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ; UNFOLDED-PROTEIN RESPONSE ; ADIPOCYTE DIFFERENTIATION ; CONGENITAL LIPODYSTROPHY ; INTRACELLULAR CALCIUM ; LIPID MOBILIZATION ; CA2+ ; METABOLISM ; ACTIVATION ; OBESITY
英文摘要:

Adipose tissue is central to the regulation of lipid metabolism. Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), one of the most severe lipodystrophy diseases, is caused by mutation of the Seipin gene. Seipin plays an important role in adipocyte differentiation and lipid homeostasis, but its exact molecular functions are still unknown. Here, we show that Seipin physically interacts with the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in both Drosophila and man. SERCA, an endoplasmic reticulum (ER) calcium pump, is solely responsible for transporting cytosolic calcium into the ER lumen. Like dSeipin, dSERCA cell-autonomously promotes lipid storage in Drosophila fat cells. dSeipin affects dSERCA activity and modulates intracellular calcium homeostasis. Adipose tissue-specific knockdown of the ER-to-cytosol calcium release channel ryanodine receptor (RyR) partially restores fat storage in dSeipin mutants. Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis.

语种: 英语
所属项目编号: 2013CB530606 ; 2009CB919000 ; 2011CB503900 ; 31325018 ; 81121061
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China (NSFC) ; NSFC
WOS记录号: WOS:000335561200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57606
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China

Recommended Citation:
Bi, Junfeng,Wang, Wei,Liu, Zhonghua,et al. Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA[J]. CELL METABOLISM,2014,19(5):861-871.
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