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学科主题基础医学
Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA
Bi, Junfeng1,2; Wang, Wei1; Liu, Zhonghua1; Huang, Xiahe1; Jiang, Qingqing1,3,4; Liu, George3,4; Wang, Yingchun; Huang, Xun1
刊名CELL METABOLISM
2014-05-06
DOI10.1016/j.cmet.2014.03.028
19期:5页:861-871
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Endocrinology & Metabolism
研究领域[WOS]Cell Biology ; Endocrinology & Metabolism
关键词[WOS]ENDOPLASMIC-RETICULUM STRESS ; UNFOLDED-PROTEIN RESPONSE ; ADIPOCYTE DIFFERENTIATION ; CONGENITAL LIPODYSTROPHY ; INTRACELLULAR CALCIUM ; LIPID MOBILIZATION ; CA2+ ; METABOLISM ; ACTIVATION ; OBESITY
英文摘要

Adipose tissue is central to the regulation of lipid metabolism. Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), one of the most severe lipodystrophy diseases, is caused by mutation of the Seipin gene. Seipin plays an important role in adipocyte differentiation and lipid homeostasis, but its exact molecular functions are still unknown. Here, we show that Seipin physically interacts with the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in both Drosophila and man. SERCA, an endoplasmic reticulum (ER) calcium pump, is solely responsible for transporting cytosolic calcium into the ER lumen. Like dSeipin, dSERCA cell-autonomously promotes lipid storage in Drosophila fat cells. dSeipin affects dSERCA activity and modulates intracellular calcium homeostasis. Adipose tissue-specific knockdown of the ER-to-cytosol calcium release channel ryanodine receptor (RyR) partially restores fat storage in dSeipin mutants. Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis.

语种英语
WOS记录号WOS:000335561200014
项目编号2013CB530606 ; 2009CB919000 ; 2011CB503900 ; 31325018 ; 81121061
资助机构National Basic Research Program of China ; National Natural Science Foundation of China (NSFC) ; NSFC
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57606
专题北京大学基础医学院_心血管所
作者单位1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China
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GB/T 7714
Bi, Junfeng,Wang, Wei,Liu, Zhonghua,et al. Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA[J]. CELL METABOLISM,2014,19(5):861-871.
APA Bi, Junfeng.,Wang, Wei.,Liu, Zhonghua.,Huang, Xiahe.,Jiang, Qingqing.,...&Huang, Xun.(2014).Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA.CELL METABOLISM,19(5),861-871.
MLA Bi, Junfeng,et al."Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA".CELL METABOLISM 19.5(2014):861-871.
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