IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Histopathological Study of Murine Pulmonary Cryptococcosis Induced by Cryptococcus gattii and Cryptococcus neoformans
Okubo, Yoichiro1; Wakayama, Megumi1; Ohno, Hideaki2; Yamamoto, Shuhei2; Tochigi, Naobumi1; Tanabe, Koichi2; Kaneko, Yukihiro2; Yamagoe, Satoshi2; Umeyama, Takashi2; Shinozaki, Minoru1; Nemoto, Tetsuo1; Nakayama, Haruo3; Sasai, Daisuke1; Ishiwatari, Takao1; Shimodaira, Kayoko1; Yamamoto, Yoshiro1; Kamei, Katsuhiko4; Miyazaki, Yoshitsugu2; Shibuya, Kazutoshi1,5
刊名JAPANESE JOURNAL OF INFECTIOUS DISEASES
2013-05-01
66期:3页:216-221
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
资助者Ministry of Health, Labour and Welfare of Japan ; Strategic Basis on Research Grounds for Non-governmental Schools at Heisei 20th ; Strategic Research Foundation ; KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School ; Ministry of Health, Labour and Welfare of Japan ; Strategic Basis on Research Grounds for Non-governmental Schools at Heisei 20th ; Strategic Research Foundation ; KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School
研究领域[WOS]Infectious Diseases
英文摘要

Although Cryptococcus gattii can cause life-threatening complications, putative virulence factors of C. gattii remain controversial. Therefore, we conducted the present study to elucidate the virulence factors of the yeast and found that the mortality rate of mice infected with C. gattii R265 was significantly higher than that of those infected with C. gattii 5815; however, no difference was found in the mortality rates between mice infected with C. gattii R265 and Cryptococcus neoformans H99. In contrast, we found a significant difference in histopathological findings of the lungs between mice infected with C. gattii R265 and C. neoformans H99. The former showed alveolar expansion due to yeast proliferation with much lesser macrophage response, whereas the latter showed numerous nodules in the alveolar space consisting of macrophages and multinucleated giant cells. Furthermore, alveolar expansion was more enhanced in mice infected with C. gattii R265 than in those infected with C. gattii 5815. Our study confirmed that there is a different pathophysiology leading to death during C. gattii and C. neoformans infections. The result can provide two characteristics of C. gattii: one includes some mechanisms to escape from host recognition via macrophage and another includes a high performance of pulmonary structural alteration. These characteristics may be associated with the high virulence of C. gattii.

语种英语
所属项目编号H22-Shinkou-Ippan-8 ; H23-Shinkou-Ippan-018 ; H20-Nannchi-Ippann-35 ; 24790364 ; 23-19 ; 21 ; 28 ; 24-11 ; 16 ; 27
资助者Ministry of Health, Labour and Welfare of Japan ; Strategic Basis on Research Grounds for Non-governmental Schools at Heisei 20th ; Strategic Research Foundation ; KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School ; Ministry of Health, Labour and Welfare of Japan ; Strategic Basis on Research Grounds for Non-governmental Schools at Heisei 20th ; Strategic Research Foundation ; KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School
WOS记录号WOS:000320094900007
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57613
Collection北京大学第一临床医学院_皮肤性病科
作者单位1.Toho Univ, Sch Med, Dept Surg Pathol, Tokyo 1438541, Japan
2.Toho Univ, Ohashi Med Ctr, Dept Neurosurg, Tokyo 1538515, Japan
3.Natl Inst Infect Dis, Dept Chemotherapy & Mycoses, Tokyo 1628640, Japan
4.Chiba Univ, Med Mycol Res Ctr, Div Clin Res, Chiba 2608673, Japan
5.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Okubo, Yoichiro,Wakayama, Megumi,Ohno, Hideaki,et al. Histopathological Study of Murine Pulmonary Cryptococcosis Induced by Cryptococcus gattii and Cryptococcus neoformans[J]. JAPANESE JOURNAL OF INFECTIOUS DISEASES,2013,66(3):216-221.
APA Okubo, Yoichiro.,Wakayama, Megumi.,Ohno, Hideaki.,Yamamoto, Shuhei.,Tochigi, Naobumi.,...&Shibuya, Kazutoshi.(2013).Histopathological Study of Murine Pulmonary Cryptococcosis Induced by Cryptococcus gattii and Cryptococcus neoformans.JAPANESE JOURNAL OF INFECTIOUS DISEASES,66(3),216-221.
MLA Okubo, Yoichiro,et al."Histopathological Study of Murine Pulmonary Cryptococcosis Induced by Cryptococcus gattii and Cryptococcus neoformans".JAPANESE JOURNAL OF INFECTIOUS DISEASES 66.3(2013):216-221.
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