|Impact of direct sirolimus-eluting stent implantation on the early systemic inflammatory response compared with complementary stent implantation|
|Li, Jian-Jun1; Zhang, Yu-Ping; Wang, Chun2; Gao, Li-Jian1; Qin, Xue-Wen1; Xu, Bo1; Chen, Ji-Lin1; Yang, Yue-Jin1; Gao, Run-Lin1|
|关键词||Coronary Artery Disease Inflammation Sirolimus-eluting Stent|
|刊名||CORONARY ARTERY DISEASE|
|WOS标题词||Science & Technology|
|类目[WOS]||Peripheral Vascular Disease|
|研究领域[WOS]||Cardiovascular System & Cardiology|
|关键词[WOS]||CORONARY-ARTERY LESIONS ; BALLOON PREDILATATION ; STABLE ANGINA ; BARE METAL ; RESTENOSIS ; TRIAL ; ELEVATION ; STENOSIS ; SIRIUS ; SAFE|
Background Systemic inflammation after percutaneous coronary intervention (PCI) identifies patients at increased risk of subsequent major adverse cardiac event During PCI, the technique of stent implantation including direct stenting (DS) and complementary stenting (CS) is guided using both clinical and angiographic features. DS was practiced with increased frequency during PCI in an attempt to reduce both restenosis and major adverse cardiac event in the drug-eluting stent (DES) era. Impact of DS on the early inflammatory response has, however, not been investigated. We hypothesized that a direct DES implantation may attenuate the early inflammatory response compared with CS.
Purpose In this study, therefore, we prospectively select the sirolimus-eluting stent (SES) as a model of DESs, and sought to determine the early systemic inflammatory response in patients with single-vessel disease after PCI using either DS or CS techniques.
Methods Thirty-nine patients who had single-vessel disease implanted with SES were randomly enrolled into the two groups: DS group (n=20) or CS group (n=19). The blood samples were taken before PCI, 24 and 72 h after stenting. The plasma concentrations of C-reactive protein and interleukin-6 (IL-6) were determined by enzyme-linked immunosorbent assay.
Results No significant difference in baseline clinical, angiographic, and inflammatory parameters between the two groups is observed. The plasma IL-6 levels at 24 h after stent implantation were significantly higher than that at baseline in both groups (P < 0.05, respectively). Plasma IL-6 level was, however, higher in CS group than in DS group (P < 0.01) and was returned to baseline levels in both groups at 72 h after stenting. Meanwhile, the plasma levels of C-reactive protein were also significant higher in CS group compared with DS group at both 24 and 72 h after stenting (P < 0.05, respectively).
Conclusion Taken together, our findings demonstrated that a direct SES implantation significantly attenuated the early systemic inflammatory response in patients with single-vessel disease compared with CS technique. Coron Artery Dis 20:65-70 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
|项目编号||2004190 ; 30670861 ; 7082081 ; 20060023044 ; 20070023047|
|资助机构||Fu Wai Hospital Grant ; National Natural Scientific Foundation ; Beijing Natural Scientific Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education of China|
|作者单位||1.Chinese Acad Med Sci, Dept Cardiol, Fu Wai Hosp, Peking Union Med Coll, Beijing 100037, Peoples R China|
2.Peking Univ, Dept Cardiol, Shenzhen Hosp, Shenzhen, Peoples R China
|Li, Jian-Jun,Zhang, Yu-Ping,Wang, Chun,et al. Impact of direct sirolimus-eluting stent implantation on the early systemic inflammatory response compared with complementary stent implantation[J]. CORONARY ARTERY DISEASE,2009,20(1):65-70.|
|APA||Li, Jian-Jun.,Zhang, Yu-Ping.,Wang, Chun.,Gao, Li-Jian.,Qin, Xue-Wen.,...&Gao, Run-Lin.(2009).Impact of direct sirolimus-eluting stent implantation on the early systemic inflammatory response compared with complementary stent implantation.CORONARY ARTERY DISEASE,20(1),65-70.|
|MLA||Li, Jian-Jun,et al."Impact of direct sirolimus-eluting stent implantation on the early systemic inflammatory response compared with complementary stent implantation".CORONARY ARTERY DISEASE 20.1(2009):65-70.|