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学科主题: 临床医学
题名:
Lovastatin Causes Diminished PSA Secretion by Inhibiting AR Expression and Function in LNCaP Prostate Cancer Cells
作者: Yang, Lin; Egger, Martina; Plattner, Raffael; Klocker, Helmut; Eder, Iris E.1
刊名: UROLOGY
发表日期: 2011-06-01
DOI: 10.1016/j.urology.2010.12.074
卷: 77, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: COA REDUCTASE INHIBITORS ; ANDROGEN RECEPTOR ; MEVALONATE PATHWAY ; GROWTH-INHIBITION ; DOWN-REGULATION ; CHOLESTEROL ; PROLIFERATION ; P85-ALPHA ; APOPTOSIS ; RISK
英文摘要:

OBJECTIVES To investigate why statin users display a noticeable decline in prostate specific antigen (PSA) as revealed in recent clinical trials, we tested the effects of lovastatin on the androgen signaling cascade in lymph node carcinoma of the prostate (LNCaP) prostate cancer cells.

METHODS Effects of lovastatin alone or in combination with a small interference RNA to inhibit AR expression on cell proliferation and induction of apoptosis were assessed by [(3)H] thymidine incorporation and caspase-3 activity assay. PSA levels were measured in the cell culture supernatant by immunoassay. In addition, expression and activity of AR and Akt/protein kinase B (Akt) were determined by Western blotting and real-time polymerase chain reaction as well as by luciferase reporter gene assay.

RESULTS Our results show that lovastatin significantly reduces AR expression and activity, resulting in decreased PSA levels. These effects were associated with inhibition of cell proliferation and induction of apoptosis. In addition, we observed that the Akt signaling pathway plays a pivotal role in lovastatin-mediated regulation of AR signaling.

CONCLUSIONS Our data suggest that the regular use of statins may have beneficial effects in statin users by preventing prostate cancer growth through inhibition of androgen activation and expression, resulting in diminished PSA levels. UROLOGY 77: 1508.e1-1508.e7, 2011. (C) 2011 Elsevier Inc.

语种: 英语
项目资助者: Peking University First Hospital, Eurasia-Pacific Uninet ; COMET Center ONCOTYROL ; Federal Ministry for Transport Innovation and Technology (BMVIT) ; Federal Ministry of Economics and Labour/the Federal Ministry of Economy, Family and Youth (BMWA/BMWFJ) ; Tiroler Zukunftsstiftung (TZS) ; Innsbruck Medical University ; Ugichem Gesellschaft fur organische Chemie mbH ; TILAK-Tiroler Landeskrankenanstalten GmbH [TILAK-Hospital Holding Company]
WOS记录号: WOS:000291047500072
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57618
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Urol, Beijing 100871, Peoples R China
2.Natl Urol Canc Ctr, Beijing, Peoples R China
3.Innsbruck Med Univ, Dept Urol, Div Expt Urol, A-6020 Innsbruck, Austria

Recommended Citation:
Yang, Lin,Egger, Martina,Plattner, Raffael,et al. Lovastatin Causes Diminished PSA Secretion by Inhibiting AR Expression and Function in LNCaP Prostate Cancer Cells[J]. UROLOGY,2011,77(6).
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