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学科主题口腔医学
Primary Intraosseous Squamous Cell Carcinoma of the Jaws Clinicopathologic Presentation and Prognostic Factors
Huang, Jing-Wei1; Luo, Hai-Yan1; Li, Qiong2; Li, Tie-Jun1
刊名ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
2009-11-01
133期:11页:1834-1840
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology ; Medicine, Research & Experimental ; Pathology
研究领域[WOS]Medical Laboratory Technology ; Research & Experimental Medicine ; Pathology
英文摘要

Context.-Primary intraosseous squamous cell carcinoma is a rare form of squamous cell carcinoma, arising within the jaws.

Objective.-To clarify the clinicopathologic and behavioral spectrum of primary intraosseous squamous cell carcinoma.

Design.-The clinical and pathologic findings, treatment, and follow-up data of 39 cases of primary intraosseous squamous cell carcinoma were collected and analyzed.

Results.-Of the 39 patients, 26 (67%) were men and 13 (33%) were women. The age at diagnosis ranged from 24 to 82 years (mean, 54 years). The tumors occurred predominantly (84.6%) in the posterior mandible. Microscopically, all tumors demonstrated general features of a squamous cell carcinoma; 19 of which (49%) also showed features suggestive of an odontogenic origin. The overall survival rates were 69.8% at 2 years and 36.3% at 5 years. Univariate analysis showed that tumors with or without odontogenic features, tumor grading, lymph node metastasis, and treatment modalities were significant prognostic factors for survival, but multivariate analysis showed that only histologic grading (relative risk, 4.43; P = .03) remained a significant prognostic factor. The cumulative probabilities of recurrence were 55.7% at 2 years and 75.9% at 5 years. Univariate analysis showed that lymph node metastasis and treatment modalities were significant prognostic factors for recurrence. On multivariate analysis, however, only lymph node metastasis remained a significant prognostic factor (relative risk, 2.54; P = .05).

Conclusions.-Primary intraosseous squamous cell carcinoma is a high-grade malignancy with frequent, regional lymph node metastasis and high rates of recurrence and mortality. The tumor grading and regional lymph node metastasis may serve as useful indicators for prognosis. (Arch Pathol Lab Med. 2009; 133: 1834-1840)

语种英语
WOS记录号WOS:000271880500015
项目编号30625044 ; 30572048 ; 30872900 ; 20050001110
资助机构National Nature Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education in China
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57619
专题北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Sch Publ Hlth, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Huang, Jing-Wei,Luo, Hai-Yan,Li, Qiong,et al. Primary Intraosseous Squamous Cell Carcinoma of the Jaws Clinicopathologic Presentation and Prognostic Factors[J]. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE,2009,133(11):1834-1840.
APA Huang, Jing-Wei,Luo, Hai-Yan,Li, Qiong,&Li, Tie-Jun.(2009).Primary Intraosseous Squamous Cell Carcinoma of the Jaws Clinicopathologic Presentation and Prognostic Factors.ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE,133(11),1834-1840.
MLA Huang, Jing-Wei,et al."Primary Intraosseous Squamous Cell Carcinoma of the Jaws Clinicopathologic Presentation and Prognostic Factors".ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 133.11(2009):1834-1840.
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