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Effect of Conditioned Stimulus Exposure during Slow Wave Sleep on Fear Memory Extinction in Humans
He, Jia1,2,3; Sun, Hong-Qiang1,2; Li, Su-Xia3; Zhang, Wei-Hua1,2; Shi, Jie3; Ai, Si-Zhi3; Li, Yun4; Li, Xiao-Jun1,2; Tang, Xiang-Dong4; Lu, Lin1,2,3,5,6
关键词Conditioned Stimulus Extinction Fear Memory Slow Wave Sleep
刊名SLEEP
2015-03-01
DOI10.5665/sleep.4502
38期:3页:423-431
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]EYE-MOVEMENT SLEEP ; REQUIRES PROTEIN-SYNTHESIS ; LEARNING-DEPENDENT CHANGES ; LATE NOCTURNAL SLEEP ; NON-REM SLEEP ; PROCEDURAL MEMORY ; EMOTIONAL MEMORY ; CONSOLIDATION ; SPINDLES ; ENHANCEMENT
英文摘要

Study Objectives: Repeated exposure to a neutral conditioned stimulus (CS) in the absence of a noxious unconditioned stimulus (US) elicits fear memory extinction. The aim of the current study was to investigate the effects of mild tone exposure (CS) during slow wave sleep (SWS) on fear memory extinction in humans.

Design: The healthy volunteers underwent an auditory fear conditioning paradigm on the experimental night, during which tones served as the CS, and a mild shock served as the US. They were then randomly assigned to four groups. Three groups were exposed to the CS for 3 or 10 min or an irrelevant tone (control stimulus, CtrS) for 10 min during SWS. The fourth group served as controls and was not subjected to any interventions. All of the subjects completed a memory test 4 h after SWS-rich stage to evaluate the effect on fear extinction. Moreover, we conducted similar experiments using an independent group of subjects during the daytime to test whether the memory extinction effect was specific to the sleep condition.

Participants: Ninety-six healthy volunteers (44 males) aged 18-28 y.

Measurements and Results: Participants exhibited undisturbed sleep during 2 consecutive nights, as assessed by sleep variables (all P > 0.05) from polysomnographic recordings and power spectral analysis. Participants who were re-exposed to the 10 min CS either during SWS and wakefulness exhibited attenuated fear responses (wake-10 min CS, P < 0.05; SWS-10 min CS, P < 0.01).

Conclusions: Conditioned stimulus re-exposure during slow wave sleep promoted fear memory extinction without altering sleep profiles.

语种英语
WOS记录号WOS:000350648500013
项目编号81271489 ; 31230033 ; 81171251 ; 81328010 ; 2015CB856400
资助机构Natural Science Foundation of China ; National Basic Research Program of China
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57620
专题北京大学精神卫生研究所
北京大学医学部管理机构_医学部
北京大学精神卫生研究所_精神科
作者单位1.Natl Inst Drug Dependence, Beijing, Peoples R China
2.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Sichuan Univ, West China Hosp, Translat Neurosci Ctr, Sleep Med Ctr, Chengdu 610064, Peoples R China
5.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100191, Peoples R China
6.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
He, Jia,Sun, Hong-Qiang,Li, Su-Xia,et al. Effect of Conditioned Stimulus Exposure during Slow Wave Sleep on Fear Memory Extinction in Humans[J]. SLEEP,2015,38(3):423-431.
APA He, Jia.,Sun, Hong-Qiang.,Li, Su-Xia.,Zhang, Wei-Hua.,Shi, Jie.,...&Lu, Lin.(2015).Effect of Conditioned Stimulus Exposure during Slow Wave Sleep on Fear Memory Extinction in Humans.SLEEP,38(3),423-431.
MLA He, Jia,et al."Effect of Conditioned Stimulus Exposure during Slow Wave Sleep on Fear Memory Extinction in Humans".SLEEP 38.3(2015):423-431.
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