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学科主题: 精神卫生
题名:
Effect of Conditioned Stimulus Exposure during Slow Wave Sleep on Fear Memory Extinction in Humans
作者: He, Jia1,2,3; Sun, Hong-Qiang1,2; Li, Su-Xia3; Zhang, Wei-Hua1,2; Shi, Jie3; Ai, Si-Zhi3; Li, Yun4; Li, Xiao-Jun1,2; Tang, Xiang-Dong4; Lu, Lin1,2,3,5,6
关键词: conditioned stimulus ; extinction ; fear memory ; slow wave sleep
刊名: SLEEP
发表日期: 2015-03-01
DOI: 10.5665/sleep.4502
卷: 38, 期:3, 页:423-431
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: EYE-MOVEMENT SLEEP ; REQUIRES PROTEIN-SYNTHESIS ; LEARNING-DEPENDENT CHANGES ; LATE NOCTURNAL SLEEP ; NON-REM SLEEP ; PROCEDURAL MEMORY ; EMOTIONAL MEMORY ; CONSOLIDATION ; SPINDLES ; ENHANCEMENT
英文摘要:

Study Objectives: Repeated exposure to a neutral conditioned stimulus (CS) in the absence of a noxious unconditioned stimulus (US) elicits fear memory extinction. The aim of the current study was to investigate the effects of mild tone exposure (CS) during slow wave sleep (SWS) on fear memory extinction in humans.

Design: The healthy volunteers underwent an auditory fear conditioning paradigm on the experimental night, during which tones served as the CS, and a mild shock served as the US. They were then randomly assigned to four groups. Three groups were exposed to the CS for 3 or 10 min or an irrelevant tone (control stimulus, CtrS) for 10 min during SWS. The fourth group served as controls and was not subjected to any interventions. All of the subjects completed a memory test 4 h after SWS-rich stage to evaluate the effect on fear extinction. Moreover, we conducted similar experiments using an independent group of subjects during the daytime to test whether the memory extinction effect was specific to the sleep condition.

Participants: Ninety-six healthy volunteers (44 males) aged 18-28 y.

Measurements and Results: Participants exhibited undisturbed sleep during 2 consecutive nights, as assessed by sleep variables (all P > 0.05) from polysomnographic recordings and power spectral analysis. Participants who were re-exposed to the 10 min CS either during SWS and wakefulness exhibited attenuated fear responses (wake-10 min CS, P < 0.05; SWS-10 min CS, P < 0.01).

Conclusions: Conditioned stimulus re-exposure during slow wave sleep promoted fear memory extinction without altering sleep profiles.

语种: 英语
所属项目编号: 81271489 ; 31230033 ; 81171251 ; 81328010 ; 2015CB856400
项目资助者: Natural Science Foundation of China ; National Basic Research Program of China
WOS记录号: WOS:000350648500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57620
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Natl Inst Drug Dependence, Beijing, Peoples R China
2.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Sichuan Univ, West China Hosp, Translat Neurosci Ctr, Sleep Med Ctr, Chengdu 610064, Peoples R China
5.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100191, Peoples R China
6.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100191, Peoples R China

Recommended Citation:
He, Jia,Sun, Hong-Qiang,Li, Su-Xia,et al. Effect of Conditioned Stimulus Exposure during Slow Wave Sleep on Fear Memory Extinction in Humans[J]. SLEEP,2015,38(3):423-431.
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