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Serum progesterone concentration on day of HCG administration and IVF outcome
Li, R.; Qiao, J.; Wang, L.; Zhen, X.; Lu, Y.
关键词Embryo Transfer Ivf Premature Luteinization Progesterone
刊名REPRODUCTIVE BIOMEDICINE ONLINE
2008-05-01
16期:5页:627-631
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]FOLLICLE-STIMULATING-HORMONE ; PREMATURE LUTEINIZATION ; GNRH ANTAGONIST ; GONADOTROPIN ; CYCLES ; RISE
英文摘要

To determine the relationship between serum progesterone on the day of human chorionic gonadotrophin (HCG) and the pregnancy outcome of IVF-embryo transfer treatment, 251 infertile patients undergoing IVF-embryo transfer with gonadotrophin-releasing hormone agonist (GnRHa) and recombinant FSH (rFSH) were prospectively studied. Among them, If 8 patients Underwent 118 cycles of frozen embryo transfer (FET) treatment, one cycle per patient. All the cycles were grouped according to serum progesterone concentration on the day of HCG administration (<3.97 nmol/l or >= 3.97 nmol/l). The incidence of progesterone elevation was 36.7% (92/251), and in this group the pregnancy rate was significantly lower (25.97 versus 48.57%; P < 0.001). If the serum progesterone on the day of HCG was over 6.0 nmol/l, their pregnancy outcome was much poorer (13.79 versus 44.68%). However, the pregnancy rate was similar in FET cycles whether the serum progesterone was over 3.97 nmol/l (34.00 versus 36.76%) or 6.0 nmol/l (42.86 versus 34.02%). In conclusion, serum progesterone on the day of HCG may predict IVF pregnancy outcome. The higher serum oestradiol and progesterone concentrations may affect endometrial receptivity. For patients with an extremely high progesterone concentration on the day of HCG (such as over 6.0 nmol/l), transfer of frozen embryos in a natural cycle is suggested.

语种英语
WOS记录号WOS:000255811800006
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被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57624
专题北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Hosp 3, Reprod Med Ctr, Dept Obstet & Gynecol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, R.,Qiao, J.,Wang, L.,et al. Serum progesterone concentration on day of HCG administration and IVF outcome[J]. REPRODUCTIVE BIOMEDICINE ONLINE,2008,16(5):627-631.
APA Li, R.,Qiao, J.,Wang, L.,Zhen, X.,&Lu, Y..(2008).Serum progesterone concentration on day of HCG administration and IVF outcome.REPRODUCTIVE BIOMEDICINE ONLINE,16(5),627-631.
MLA Li, R.,et al."Serum progesterone concentration on day of HCG administration and IVF outcome".REPRODUCTIVE BIOMEDICINE ONLINE 16.5(2008):627-631.
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