|Does an extended mediastinal lymphadenectomy improve outcome after R0 resection in lung cancer?|
|Wu, Nan; Yan, Shi; Lv, Chao; Li, Shaolei; Feng, Yuan; Wang, Yuzhao; Wang, Jia; Zheng, Qingfeng; Yang, Yue|
|关键词||Lung Cancer Lymphadenectomy Outcome Quality|
|刊名||CHINESE JOURNAL OF CANCER RESEARCH|
|WOS标题词||Science & Technology|
|关键词[WOS]||CLINICAL-PRACTICE GUIDELINES ; LYMPH-NODE DISSECTION ; STAGE-I ; RANDOMIZED-TRIAL ; AMERICAN-COLLEGE ; 2ND EDITION ; SURGERY ; IIIA|
Objective: This retrospective study was conducted to investigate the impact of more extended mediastinal lymphadenectomy on the outcome of lung cancer patients treated with RU resection.
Methods: During the investigation period, 325 lung cancer cases were enlisted and 278 cases entered the analysis. The patients were divided into Control group (n=116) and Research group (n=162) according to the different extents of mediastinal lymph node clearance at different time periods. Three major parameters were retrospectively assessed to compare the quality of surgical care: extent of lymph node clearance, resection volume, and postoperative recovery process and common complications. Comparison of the outcome between two groups was carried out.
Results: Research group showed a significant quality improvement of lymphadenectomy, such as more mediastinal node stations investigated (more than 3 N2 stations investigated: Research group, 90.7% vs. Control group, 55.2%; P=0.001) and more nodes collection (total nodes 26.1 +/- 10.0 vs. 19.1 +/- 8.3, P=0.000; N2 nodes 15.5 +/- 7.2 vs. 9.8 +/- 5.6, P=0.000). However, overall survival (OS) and disease-free survival (DFS) were not significantly different either between two groups (5-year OS: Control group, 56.4 +/- 4.6% vs. Research group, 62.6 +/- 4.3%; P=0.271) or between subgroups from stage I to IIIa. TNM stage and histology were significant factors associated with OS and DFS in multivariate analysis; extent of mediastinal lymphadenectomy was not associated with OS or DFS.
Conclusions: More radical mediastinal lymphadenectomy may not lead to an improved oncological outcome for lung cancer treated with R0 resection.
|作者单位||Peking Univ Canc Hosp & Inst, Minist Educ, Dept Thorac Surg 2, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China|
|Wu, Nan,Yan, Shi,Lv, Chao,et al. Does an extended mediastinal lymphadenectomy improve outcome after R0 resection in lung cancer?[J]. CHINESE JOURNAL OF CANCER RESEARCH,2014,26(2):183-191.|
|APA||Wu, Nan.,Yan, Shi.,Lv, Chao.,Li, Shaolei.,Feng, Yuan.,...&Yang, Yue.(2014).Does an extended mediastinal lymphadenectomy improve outcome after R0 resection in lung cancer?.CHINESE JOURNAL OF CANCER RESEARCH,26(2),183-191.|
|MLA||Wu, Nan,et al."Does an extended mediastinal lymphadenectomy improve outcome after R0 resection in lung cancer?".CHINESE JOURNAL OF CANCER RESEARCH 26.2(2014):183-191.|