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学科主题临床医学
Does an extended mediastinal lymphadenectomy improve outcome after R0 resection in lung cancer?
Wu, Nan; Yan, Shi; Lv, Chao; Li, Shaolei; Feng, Yuan; Wang, Yuzhao; Wang, Jia; Zheng, Qingfeng; Yang, Yue
关键词Lung Cancer Lymphadenectomy Outcome Quality
刊名CHINESE JOURNAL OF CANCER RESEARCH
2014-04-01
DOI10.3978/j.issn.1000-9604.2014.04.03
26期:2页:183-191
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CLINICAL-PRACTICE GUIDELINES ; LYMPH-NODE DISSECTION ; STAGE-I ; RANDOMIZED-TRIAL ; AMERICAN-COLLEGE ; 2ND EDITION ; SURGERY ; IIIA
英文摘要

Objective: This retrospective study was conducted to investigate the impact of more extended mediastinal lymphadenectomy on the outcome of lung cancer patients treated with RU resection.

Methods: During the investigation period, 325 lung cancer cases were enlisted and 278 cases entered the analysis. The patients were divided into Control group (n=116) and Research group (n=162) according to the different extents of mediastinal lymph node clearance at different time periods. Three major parameters were retrospectively assessed to compare the quality of surgical care: extent of lymph node clearance, resection volume, and postoperative recovery process and common complications. Comparison of the outcome between two groups was carried out.

Results: Research group showed a significant quality improvement of lymphadenectomy, such as more mediastinal node stations investigated (more than 3 N2 stations investigated: Research group, 90.7% vs. Control group, 55.2%; P=0.001) and more nodes collection (total nodes 26.1 +/- 10.0 vs. 19.1 +/- 8.3, P=0.000; N2 nodes 15.5 +/- 7.2 vs. 9.8 +/- 5.6, P=0.000). However, overall survival (OS) and disease-free survival (DFS) were not significantly different either between two groups (5-year OS: Control group, 56.4 +/- 4.6% vs. Research group, 62.6 +/- 4.3%; P=0.271) or between subgroups from stage I to IIIa. TNM stage and histology were significant factors associated with OS and DFS in multivariate analysis; extent of mediastinal lymphadenectomy was not associated with OS or DFS.

Conclusions: More radical mediastinal lymphadenectomy may not lead to an improved oncological outcome for lung cancer treated with R0 resection.

语种英语
WOS记录号WOS:000335622200009
项目编号XDA06020101 ; 81350028 ; 2012AA02A502 ; Z111107067311018
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program) ; Beijing Municipal Science &amp ; Technology Commission
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57625
专题北京大学临床肿瘤学院_胸外科
北京大学临床肿瘤学院_胸部肿瘤外二科
作者单位Peking Univ Canc Hosp & Inst, Minist Educ, Dept Thorac Surg 2, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
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GB/T 7714
Wu, Nan,Yan, Shi,Lv, Chao,et al. Does an extended mediastinal lymphadenectomy improve outcome after R0 resection in lung cancer?[J]. CHINESE JOURNAL OF CANCER RESEARCH,2014,26(2):183-191.
APA Wu, Nan.,Yan, Shi.,Lv, Chao.,Li, Shaolei.,Feng, Yuan.,...&Yang, Yue.(2014).Does an extended mediastinal lymphadenectomy improve outcome after R0 resection in lung cancer?.CHINESE JOURNAL OF CANCER RESEARCH,26(2),183-191.
MLA Wu, Nan,et al."Does an extended mediastinal lymphadenectomy improve outcome after R0 resection in lung cancer?".CHINESE JOURNAL OF CANCER RESEARCH 26.2(2014):183-191.
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