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学科主题: 临床医学
题名:
Human Serum Metabonomic Analysis Reveals Progression Axes for Glucose Intolerance and Insulin Resistance Statuses
作者: Zhang, Xiuying2; Wang, Yulan1; Hao, Fuhua1; Zhou, Xianghai2; Han, Xueyao2; Tang, Huiru1; Ji, Linong2
关键词: glucose intolerance ; insulin resistance ; metabonomics ; NMR ; gut microbtota
刊名: JOURNAL OF PROTEOME RESEARCH
发表日期: 2009-11-01
DOI: 10.1021/pr900524z
卷: 8, 期:11, 页:5188-5195
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: NUCLEAR-MAGNETIC-RESONANCE ; TYPE-2 DIABETES-MELLITUS ; MULTIVARIATE STATISTICAL-ANALYSIS ; GENOME-WIDE ASSOCIATION ; METABOLIC-RESPONSES ; SCHISTOSOMA-MANSONI ; BLOOD-PLASMA ; MODEL ; SPECTROSCOPY ; DISEASE
英文摘要:

Understanding the metabolic basis of glucose intolerances and insulin resistance is essential to facilitate early diagnosis, satisfactory therapies and personalized treatments of type 2 diabetes (T2DM). Here, we analyzed the serum metabolic variations from 231 human participants with normal glucose tolerance (NGT, n = 80, M/F = 34/46, mean age 53 +/- 10 years), impaired glucose regulation (IGR, n = 77, M/F = 33/44, mean age 51 +/- 10 years) and T2DM (n = 74, M/F = 32/42, mean age 51 +/- 9 years) to establish the relationship between the serum metabolite compositions and the development of diabetes By using the proton nuclear magnetic resonance spectroscopy in conjunction with the multivariate data analysis, we found that the development of both glucose intolerances and insulin resistances are closely correlated with the progressive changes of human serum metabonome. Compared with NGT subjects, the IGR and T2DM participants showed clear dysfunctions of choline metabolism, glucose metabolism, lipid and amino acid metabolisms, and disruptions of TCA cycle. The insulin resistance statuses were closely associated with the serum metabonomic changes in terms of glucose, fatty acid and protein/amino acid metabolisms We also found greater metabonomic heterogeneity among the populations with T2DM and high insulin resistance status. These findings provide useful information to bridge the gaps in our understandings to the metabolic alterations associated with the progression of glucose intolerances and insulin resistance status

语种: 英语
所属项目编号: 200603503900 ; 200703914701 ; 2006AA02A409 ; 20825520 ; KSCX1-YW-02
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program ; National Natural Science Foundation of China ; Chinese Academy of Sciences
WOS记录号: WOS:000276949600027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57630
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
2.Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Ctr Diabet, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Xiuying,Wang, Yulan,Hao, Fuhua,et al. Human Serum Metabonomic Analysis Reveals Progression Axes for Glucose Intolerance and Insulin Resistance Statuses[J]. JOURNAL OF PROTEOME RESEARCH,2009,8(11):5188-5195.
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