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Inhibition of Metastatic Tumor Growth and Metastasis via Targeting Metastatic Breast Cancer by Chlorotoxin-Modified Liposomes
Qin, Chao1,2; He, Bing2; Dai, Wenbing2; Zhang, Hua2; Wang, Xueqing2; Wang, Jiancheng2; Zhang, Xuan2; Wang, Guangji1; Yin, Lifang1,2; Zhang, Qiang2
关键词Chlorotoxin Modified Liposomes Targeting Delivery Metastatic Breast Cancer Antimetastasis
刊名MOLECULAR PHARMACEUTICS
2014-10-01
DOI10.1021/mp400691z
11期:10页:3233-3241
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]CELL INVASION ; GLIOMA ; EXPRESSION ; METALLOPROTEINASES ; NANOPARTICLES ; DOXORUBICIN ; STATISTICS ; SCORPION ; CHANNELS ; MODELS
英文摘要

A liposome system modified with chlorotoxin (ClTx), a scorpion venom peptide previously utilized for targeting brain tumors, was established. Its targeting efficiency and antimetastasis behavior against metastatic breast cancer highly expressed MMP-2, the receptor of ClTx, were investigated. 4T1, a metastatic breast cancer cell line derived from a murine breast tumor, was selected as the cell model. As results, the ClTx-modified liposomes displayed specific binding to 4T1 as determined by flow cytometry and confocal imaging. The cytotoxicity assay revealed that the ClTx modification increased the toxicity compared with nonmodified liposomes. In addition, the modified liposomes also exhibited high in vivo targeting efficiency in the BALB/c mice bearing 4T1 tumors. Importantly, this system inhibited the growth of metastatic tumor and prevented the incidence of lung metastasis in mice bearing 4T1 tumors with only low systemic toxicity. The data obtained from the in vitro and in vivo studies confirmed that the ClTx-modified liposomes increased the drug delivery to metastatic breast cancers. This study proved that the ClTx-modified liposomes had targeting ability to metastatic breast cancer in addition to brain cancer, and displayed an obvious antimetastasis effect. Generally, it may provide a promising strategy for metastatic breast cancer therapy.

语种英语
WOS记录号WOS:000342857000002
项目编号81130059 ; 2009CB930300 ; BMU20110263
资助机构National Natural Science Foundation of China ; National Research Fund for Fundamental Key Project ; Ministry of Education
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57632
专题北京大学药学院
北京大学基础医学院
北京大学药学院_药剂学系
作者单位1.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Qin, Chao,He, Bing,Dai, Wenbing,et al. Inhibition of Metastatic Tumor Growth and Metastasis via Targeting Metastatic Breast Cancer by Chlorotoxin-Modified Liposomes[J]. MOLECULAR PHARMACEUTICS,2014,11(10):3233-3241.
APA Qin, Chao.,He, Bing.,Dai, Wenbing.,Zhang, Hua.,Wang, Xueqing.,...&Zhang, Qiang.(2014).Inhibition of Metastatic Tumor Growth and Metastasis via Targeting Metastatic Breast Cancer by Chlorotoxin-Modified Liposomes.MOLECULAR PHARMACEUTICS,11(10),3233-3241.
MLA Qin, Chao,et al."Inhibition of Metastatic Tumor Growth and Metastasis via Targeting Metastatic Breast Cancer by Chlorotoxin-Modified Liposomes".MOLECULAR PHARMACEUTICS 11.10(2014):3233-3241.
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