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学科主题: 药学
题名:
Inhibition of Metastatic Tumor Growth and Metastasis via Targeting Metastatic Breast Cancer by Chlorotoxin-Modified Liposomes
作者: Qin, Chao1,2; He, Bing2; Dai, Wenbing2; Zhang, Hua2; Wang, Xueqing2; Wang, Jiancheng2; Zhang, Xuan2; Wang, Guangji1; Yin, Lifang1,2; Zhang, Qiang2
关键词: chlorotoxin ; modified liposomes ; targeting delivery ; metastatic breast cancer ; antimetastasis
刊名: MOLECULAR PHARMACEUTICS
发表日期: 2014-10-01
DOI: 10.1021/mp400691z
卷: 11, 期:10, 页:3233-3241
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: CELL INVASION ; GLIOMA ; EXPRESSION ; METALLOPROTEINASES ; NANOPARTICLES ; DOXORUBICIN ; STATISTICS ; SCORPION ; CHANNELS ; MODELS
英文摘要:

A liposome system modified with chlorotoxin (ClTx), a scorpion venom peptide previously utilized for targeting brain tumors, was established. Its targeting efficiency and antimetastasis behavior against metastatic breast cancer highly expressed MMP-2, the receptor of ClTx, were investigated. 4T1, a metastatic breast cancer cell line derived from a murine breast tumor, was selected as the cell model. As results, the ClTx-modified liposomes displayed specific binding to 4T1 as determined by flow cytometry and confocal imaging. The cytotoxicity assay revealed that the ClTx modification increased the toxicity compared with nonmodified liposomes. In addition, the modified liposomes also exhibited high in vivo targeting efficiency in the BALB/c mice bearing 4T1 tumors. Importantly, this system inhibited the growth of metastatic tumor and prevented the incidence of lung metastasis in mice bearing 4T1 tumors with only low systemic toxicity. The data obtained from the in vitro and in vivo studies confirmed that the ClTx-modified liposomes increased the drug delivery to metastatic breast cancers. This study proved that the ClTx-modified liposomes had targeting ability to metastatic breast cancer in addition to brain cancer, and displayed an obvious antimetastasis effect. Generally, it may provide a promising strategy for metastatic breast cancer therapy.

语种: 英语
所属项目编号: 81130059 ; 2009CB930300 ; BMU20110263
项目资助者: National Natural Science Foundation of China ; National Research Fund for Fundamental Key Project ; Ministry of Education
WOS记录号: WOS:000342857000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57632
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Qin, Chao,He, Bing,Dai, Wenbing,et al. Inhibition of Metastatic Tumor Growth and Metastasis via Targeting Metastatic Breast Cancer by Chlorotoxin-Modified Liposomes[J]. MOLECULAR PHARMACEUTICS,2014,11(10):3233-3241.
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