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学科主题: 基础医学
题名:
Thyroid Hormone Attenuates Vascular Calcification Induced by Vitamin D3 Plus Nicotine in Rats
作者: Zhang, Jing1; Chang, Jin-Rui2; Duan, Xiao-Hui2; Yu, Yan-Rong2; Zhang, Bao-Hong3
关键词: Thyroid hormone ; Vascular calcification ; Vitamin D-3 plus nicotine
刊名: CALCIFIED TISSUE INTERNATIONAL
发表日期: 2015
DOI: 10.1007/s00223-014-9934-8
卷: 96, 期:1, 页:80-87
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: SMOOTH-MUSCLE-CELLS ; OSTEOBLASTIC DIFFERENTIATION ; HEMODIALYSIS-PATIENTS ; ARTERY CALCIFICATION ; BONE-FORMATION ; EXPRESSION ; PHOSPHATE ; DENSITY ; DISEASE ; HEART
英文摘要:

Thyroid hormones (THs) including thyroxine (T-4) and triiodothyronine (T-3) play critical roles in bone remodeling. However, the role and mechanism of THs in vascular calcification (VC) have been unclear. To explore the pathophysiological roles of T3 on VC, we investigated the changes in plasma and aortas of THs concentrations and the effect of T3 on rat VC induced by vitamin D3 plus nicotine (VDN). VDN-treated rat showed decreased plasma T3 content, increased vascular calcium deposition, and alkaline phosphatase (ALP) activity. Administration of T3 (0.2 mg/kg body weight IP) for 10 days greatly reduced vascular calcium deposition and ALP activity in calcified rat aortas when compared with controls. Concurrently, the loss of smooth muscle lineage markers alpha-actin and SM22a was restored, and the increased bone-associated molecules, such as runt-related transcription factor2 (Runx2), Osterix, and osteopontin (OPN) levels in calcified aorta, were reduced by administration of T3. The suppression of klotho in calcified rat aorta was restored by T3. Methimazole (400 mg/L) blocked the beneficial effect of T3 on VC. These results suggested that T3 can inhibit VC development.

语种: 英语
所属项目编号: 81370972 ; 30600232
项目资助者: National Natural Sciences Foundation of China
WOS记录号: WOS:000347709400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57653
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Hosp Tsinghua Univ, Beijing 100084, Peoples R China
2.Beijing Normal Univ, Sch PE & Sports Sci, Beijing 100875, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Lab Cardiovasc Bioact Mol, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Jing,Chang, Jin-Rui,Duan, Xiao-Hui,et al. Thyroid Hormone Attenuates Vascular Calcification Induced by Vitamin D3 Plus Nicotine in Rats[J]. CALCIFIED TISSUE INTERNATIONAL,2015,96(1):80-87.
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