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学科主题: 药学
题名:
New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production
作者: Cao, Gui-Yun1; Xu, Wei1; Yang, Xiu-Wei1; Gonzalez, Frank J.2; Li, Fei2
关键词: Myristica fragrans ; Neolignans ; Nitric oxide ; Inhibition ; iNOS mRNA
刊名: FOOD CHEMISTRY
发表日期: 2015-04-15
DOI: 10.1016/j.foodchem.2014.09.170
卷: 173, 页:231-237
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]: Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]: ABSOLUTE-CONFIGURATION ASSIGNMENT ; ENANTIOSELECTIVE SYNTHESIS ; NUTMEG ; LIGNANS ; MACE ; CONSTITUENTS ; ANTIOXIDANT ; MODEL ; RAT
英文摘要:

Five new 8-0-4′ type neolignans, named myrifralignan A-E (1-5), together with five known analogues (6-10), were isolated from the seeds of Myristica fragrans Houtt. Their chemical structures were determined using several spectroscopic methods. Compounds 3-10 exhibited potent inhibitory activity against the production of nitric oxide (NO) in the RAW264.7 cell line stimulated by lipopolysaccaride. Myrislignan (7) and machilin D (10) were the most potent inhibitors of NO production amongst these compounds. The IC50 values of myrislignan and machilin D were 21.2 and 18.5 mu M. And, their inhibitory activity was more than L-N-6-(1-iminoethyl)-lysine, a selective inhibitor of inducible nitric oxide synthase (IC50 = 27.1 mu M). Furthermore, real-time PCR analysis revealed that these neolignans could significantly suppress the expression of inducible nitric oxide synthase mRNA. These results demonstrated that the 8-0-4′ type neolignans are promising candidates as anti-inflammatory agents. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2011BAI07B08 ; 30973863 ; 81161120429
项目资助者: National Key Technologies R&amp ; D Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000347755800030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57656
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med,State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Recommended Citation:
Cao, Gui-Yun,Xu, Wei,Yang, Xiu-Wei,et al. New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production[J]. FOOD CHEMISTRY,2015,173:231-237.
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