北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Evaluation on drug dependence of buprenorphine
作者: Liu, ZM; Lu, XX; Lian, Z; Mu, Y; Guo, P; An, X
关键词: buprenorphine ; narcotic dependence ; drug evaluation
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2003-05-01
卷: 24, 期:5, 页:448-452
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: HEROIN ; DETOXIFICATION ; ADDICTS
英文摘要:

Aim: To survey and assess the drug dependence and abuse potential liability of buprenorphine among opiate abusers. Methods: Subjects of opiate dependence with history of buprenorphine use for 3 d at least were surveyed by interview. Physical dependence of buprenorphine was assessed using 30 items opiate withdrawal scale (OWS), which composed of 30 symptoms/signs. A 4-point scale was used to rate each symptoms/signs: zero (0), mild (1), moderate (2), and severe (3). Subjects were asked to rate their symptoms according to severity of previous experienced buprenorphine withdrawal. The estimate of the degree of subjective euphoria for buprenorphine was assessed using visual analogue scale (VAS). Results: Subjects 1235 who met the research criteria cases completed this survey in multi-detoxification treatment centers. The main initial purposes of buprenorphine use were detoxification (77.4%) and protracted abstinence treated (26.6%) respectively. The scores of OWS of buprenorphine were between 0.2 to 1.3; The mean scores of OWS in 3 different categories of frequency of buprenorphine use on "continuous use", "un-continuous use", and "sometimes continuous, sometimes un-continuous" were 0.9+/-0.9, 0.4+/-0.5, and 0.7+/-0.4, respectively (F=70.846, P<0.05). The degree of subjective euphoria for buprenorphine was slight to sub-moderate (mean score of VAS was 27 mm +/- 24 mm). The mean scores of VAS in different routes of buprenorphine administration of sublingual and injection were (24 +/- 23) mm. and (27 +/- 24) mm, respectively. No significant difference was found between sublingual and injection use of buprenorphine (u=1.516, P>0.05). Conclusion: Both physical and psychic,dependence of buprenorphine were low.

语种: 英语
WOS记录号: WOS:000182553500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57658
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China

Recommended Citation:
Liu, ZM,Lu, XX,Lian, Z,et al. Evaluation on drug dependence of buprenorphine[J]. ACTA PHARMACOLOGICA SINICA,2003,24(5):448-452.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, ZM]'s Articles
[Lu, XX]'s Articles
[Lian, Z]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, ZM]‘s Articles
[Lu, XX]‘s Articles
[Lian, Z]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace