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Evaluation on drug dependence of buprenorphine
Liu, ZM; Lu, XX; Lian, Z; Mu, Y; Guo, P; An, X
关键词Buprenorphine Narcotic Dependence Drug Evaluation
刊名ACTA PHARMACOLOGICA SINICA
2003-05-01
24期:5页:448-452
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]HEROIN ; DETOXIFICATION ; ADDICTS
英文摘要

Aim: To survey and assess the drug dependence and abuse potential liability of buprenorphine among opiate abusers. Methods: Subjects of opiate dependence with history of buprenorphine use for 3 d at least were surveyed by interview. Physical dependence of buprenorphine was assessed using 30 items opiate withdrawal scale (OWS), which composed of 30 symptoms/signs. A 4-point scale was used to rate each symptoms/signs: zero (0), mild (1), moderate (2), and severe (3). Subjects were asked to rate their symptoms according to severity of previous experienced buprenorphine withdrawal. The estimate of the degree of subjective euphoria for buprenorphine was assessed using visual analogue scale (VAS). Results: Subjects 1235 who met the research criteria cases completed this survey in multi-detoxification treatment centers. The main initial purposes of buprenorphine use were detoxification (77.4%) and protracted abstinence treated (26.6%) respectively. The scores of OWS of buprenorphine were between 0.2 to 1.3; The mean scores of OWS in 3 different categories of frequency of buprenorphine use on "continuous use", "un-continuous use", and "sometimes continuous, sometimes un-continuous" were 0.9+/-0.9, 0.4+/-0.5, and 0.7+/-0.4, respectively (F=70.846, P<0.05). The degree of subjective euphoria for buprenorphine was slight to sub-moderate (mean score of VAS was 27 mm +/- 24 mm). The mean scores of VAS in different routes of buprenorphine administration of sublingual and injection were (24 +/- 23) mm. and (27 +/- 24) mm, respectively. No significant difference was found between sublingual and injection use of buprenorphine (u=1.516, P>0.05). Conclusion: Both physical and psychic,dependence of buprenorphine were low.

语种英语
WOS记录号WOS:000182553500012
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57658
专题中国药物依赖性研究所
作者单位Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liu, ZM,Lu, XX,Lian, Z,et al. Evaluation on drug dependence of buprenorphine[J]. ACTA PHARMACOLOGICA SINICA,2003,24(5):448-452.
APA Liu, ZM,Lu, XX,Lian, Z,Mu, Y,Guo, P,&An, X.(2003).Evaluation on drug dependence of buprenorphine.ACTA PHARMACOLOGICA SINICA,24(5),448-452.
MLA Liu, ZM,et al."Evaluation on drug dependence of buprenorphine".ACTA PHARMACOLOGICA SINICA 24.5(2003):448-452.
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