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学科主题: 药学
题名:
Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert
作者: Nan, Ze-dong1; Zeng, Ke-wu1; Shi, She-po2; Zhao, Ming-bo1; Jiang, Yong1; Tu, Peng-fei1
关键词: Cistanche deserticola ; Phenylethanoid glycoside ; Cistanoside ; Anti-inflammatory activity
刊名: FITOTERAPIA
发表日期: 2013-09-01
DOI: 10.1016/j.fitote.2013.05.008
卷: 89, 页:167-174
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ALPHA-INDUCED APOPTOSIS ; PHENYLPROPANOID GLYCOSIDES ; NEURONAL CELLS ; CONSTITUENTS ; HERBA ; CHEMOSENSITIVITY ; ASSAY
英文摘要:

Five new phenylethanoid glycosides, cistanosides J-N (1-5), together with 15 known ones (6-20) were isolated from the stems of Cistanche deserticola cultured in Tarim desert, China. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR) and chemical degradation. All the compounds obtained were examined for their inhibitory effect on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse microglial cells (BV-2 cells), and compounds 2 and 8 showed potent inhibition on the NO production with IC50 values of 14.94 mu M and 14.32 mu M, respectively. (c) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2012ZX09201201-001 ; 2012ZX09301002-002-002 ; 2012ZX09304-005 ; 201307002
项目资助者: National Key Technology R&amp ; D Program "New Drug Innovation" of China ; International Quality Standards R&amp ; D Program of Traditional Chinese Medicine
WOS记录号: WOS:000323856500018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57660
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China

Recommended Citation:
Nan, Ze-dong,Zeng, Ke-wu,Shi, She-po,et al. Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert[J]. FITOTERAPIA,2013,89:167-174.
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