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Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert
Nan, Ze-dong1; Zeng, Ke-wu1; Shi, She-po2; Zhao, Ming-bo1; Jiang, Yong1; Tu, Peng-fei1
关键词Cistanche Deserticola Phenylethanoid Glycoside Cistanoside Anti-inflammatory Activity
刊名FITOTERAPIA
2013-09-01
DOI10.1016/j.fitote.2013.05.008
89页:167-174
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Key Technology R&amp ; D Program "New Drug Innovation" of China ; International Quality Standards R&amp ; D Program of Traditional Chinese Medicine ; National Key Technology R&amp ; D Program "New Drug Innovation" of China ; International Quality Standards R&amp ; D Program of Traditional Chinese Medicine
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ALPHA-INDUCED APOPTOSIS ; PHENYLPROPANOID GLYCOSIDES ; NEURONAL CELLS ; CONSTITUENTS ; HERBA ; CHEMOSENSITIVITY ; ASSAY
英文摘要

Five new phenylethanoid glycosides, cistanosides J-N (1-5), together with 15 known ones (6-20) were isolated from the stems of Cistanche deserticola cultured in Tarim desert, China. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR) and chemical degradation. All the compounds obtained were examined for their inhibitory effect on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse microglial cells (BV-2 cells), and compounds 2 and 8 showed potent inhibition on the NO production with IC50 values of 14.94 mu M and 14.32 mu M, respectively. (c) 2013 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2012ZX09201201-001 ; 2012ZX09301002-002-002 ; 2012ZX09304-005 ; 201307002
资助者National Key Technology R&amp ; D Program "New Drug Innovation" of China ; International Quality Standards R&amp ; D Program of Traditional Chinese Medicine ; National Key Technology R&amp ; D Program "New Drug Innovation" of China ; International Quality Standards R&amp ; D Program of Traditional Chinese Medicine
WOS记录号WOS:000323856500018
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57660
专题北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
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GB/T 7714
Nan, Ze-dong,Zeng, Ke-wu,Shi, She-po,et al. Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert[J]. FITOTERAPIA,2013,89:167-174.
APA Nan, Ze-dong,Zeng, Ke-wu,Shi, She-po,Zhao, Ming-bo,Jiang, Yong,&Tu, Peng-fei.(2013).Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert.FITOTERAPIA,89,167-174.
MLA Nan, Ze-dong,et al."Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert".FITOTERAPIA 89(2013):167-174.
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