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学科主题药学
Relationship between bilirubin free radical and formation,of pigment gallstone
Liu, XT; Hu, J
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2002-06-01
8期:3页:413-417
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]CHOLESTEROL GALLSTONE ; BILE ; CHOLECYSTOLITHIASIS ; SERUM
英文摘要

In this paper, we summarize the main progresses made in our group in the field of the mechanism of pigment gallstone formation. It was found that after treatment with free radicals, bilirubin (BR) was changed into free radical itself, and a semiquinone free radical and a superoxide free radical bound with metal were recognized, which was detected by ESR (electron spin resonance). By the means of NMR (nuclear magnetic resonance) and IR (Infra-red spectra), it was postulated that bilirubin polymerized through the reaction between the vinyl group and the hydroxyl group under the attack of free radicals. It was also found that bilirubin free radical were liable to calcify in a kinetic study. Because of its chemical properties, bilirubin free radical was shown to be cytotoxic to hepatocyte, which was demonstrated based on the following facts: induction of phospholipid peroxidation (LPO), leakage of lactate dehydrogenase (LDH) and decrease of glutathione. As to the mechanism of bilirubin-induced cytotoxicity, it was postulated that the main target of bilirubin free radical was the cell membrane, including phospholipid and membrane bound proteins, especially spectrin, a content of cytoskeleton. Based on the results mentioned above, it was deduced that bilirubin free radical is the key factor that initiates and promotes the formation of pigment gallstone, which is consistent with other researches in recent years.

语种英语
WOS记录号WOS:000176452700005
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57663
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Liu, XT,Hu, J. Relationship between bilirubin free radical and formation,of pigment gallstone[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2002,8(3):413-417.
APA Liu, XT,&Hu, J.(2002).Relationship between bilirubin free radical and formation,of pigment gallstone.WORLD JOURNAL OF GASTROENTEROLOGY,8(3),413-417.
MLA Liu, XT,et al."Relationship between bilirubin free radical and formation,of pigment gallstone".WORLD JOURNAL OF GASTROENTEROLOGY 8.3(2002):413-417.
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