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Neuroprotective effects of hydroxysafflor yellow A: In vivo and in vitro studies
Zhu, HB; Wang, ZH; Ma, CJ; Tian, JW; Fu, FH; Li, CL; Guo, D; Roeder, E; Liu, K
关键词Carthamus Tinctorius L. Compositae Hydroxysafflor Yellow a Focal Cerebral Ischemia Neuroprotection Sodium Cyanide Glutamate
刊名PLANTA MEDICA
2003-05-01
69期:5页:429-433
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]FOCAL CEREBRAL-ISCHEMIA ; GLUTAMATE RELEASE ; RAT-BRAIN ; DAMAGE
英文摘要

Previous work has shown that hydroxysafflor yellow A (HSYA), extracted from Carthamus tinctorius L. markedly extended the coagulation time in mice and exhibited a significant antithrombotic effect in rats. The present study was conducted to demonstrate further its neuroprotective effects on cerebral ischemic injury in both in vivo and in vitro studies. In vivo, male Wistar-Kyoto (WKY) rats with middle cerebral artery occlusion (MCAO) were evaluated for neurological deficit scores followed by the treatment with a single dose of HSYA. Furthermore, the infarction area of the brain was assessed in the brain slices. In vitro, the effect of HSYA was tested in cultured fetal cortical cells exposed to glutamate and sodium cyanide (NaCN) to identify its neuroprotection against neurons damage. The results in vivo showed that sublingular vein injection of HSYA at doses of 3.0 mg/kg and 6.0 mg/kg exerted significant neuroprotective effects on rats with focal cerebral ischemic injury by significantly decreasing neurological deficit scores and reducing the infarct area compared with the saline group, HSYA at a dose of 6.0 mg/kg showed a similar potency as nimodipine at a dose of 0.2 mg/kg. Sublingular vein injection of HSYA at the dose of 1.5 mg/kg showed a neuroprotective effect, however, with no significant difference when compared with the saline group. Results in vitro showed that HSYA significantly inhibited neuron damage induced by exposure to glutamate and sodium cyanide (NaCN) in cultured fetal cortical cells. Noticeably, the neuroprotective action of HSYA on glutamate-mediated neuron injury was much better than that of HSYA on NaCN-induced neuron damage. All these findings suggest that HSYA might act as a potential neuroprotective agent useful in the treatment in focal cerebral ischemia.

语种英语
WOS记录号WOS:000183697600009
引用统计
被引频次:70[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57667
专题北京大学药学院
作者单位1.Yantai Univ, Sch Pharm, Yantai 264003, Shangdong, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.Peking Union Med Coll, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100871, Peoples R China
5.Univ Bonn, Inst Pharmaceut, D-5300 Bonn, Germany
推荐引用方式
GB/T 7714
Zhu, HB,Wang, ZH,Ma, CJ,et al. Neuroprotective effects of hydroxysafflor yellow A: In vivo and in vitro studies[J]. PLANTA MEDICA,2003,69(5):429-433.
APA Zhu, HB.,Wang, ZH.,Ma, CJ.,Tian, JW.,Fu, FH.,...&Liu, K.(2003).Neuroprotective effects of hydroxysafflor yellow A: In vivo and in vitro studies.PLANTA MEDICA,69(5),429-433.
MLA Zhu, HB,et al."Neuroprotective effects of hydroxysafflor yellow A: In vivo and in vitro studies".PLANTA MEDICA 69.5(2003):429-433.
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